FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098778934> ?p ?o ?g. }

• W2098778934 endingPage "3278" @default.
• W2098778934 startingPage "3268" @default.
• W2098778934 abstract "Copper is an essential trace element and several copper containing proteins are indispensable for such processes as oxidative respiration, neural development and collagen remodeling. Copper metabolism is precisely regulated by several transporters and chaperone proteins. Copper Transport Protein 1 (CTR1) selectively uptakes copper into cells. Subsequently three chaperone proteins, HAH1 (human atx1 homologue 1), Cox17p and CCS (copper chaperone for superoxide dismutase) transport copper to the Golgi apparatus, mitochondria and copper/zinc superoxide dismutase respectively. Defects in the copper transporters ATP7A and ATP7B are responsible for Menkes disease and Wilsons disease respectively. These proteins transport copper via HAH1 to the Golgi apparatus to deliver copper to cuproenzymes. They also prevent cellular damage from an excess accumulation of copper by mediating the efflux of copper from the cell. There is increasing evidence that copper transport mechanisms may play a role in drug resistance. We, and others, found that ATP7A and ATP7B are involved in drug resistance against the anti-tumor drug cis-diamminedichloroplatinum (II) (CDDP). A relationship between the expression of ATP7A or ATP7B in tumors and CDDP resistance is supported by clinical studies. In addition, the copper uptake transporter CTR1 has also been reported to play a role in CDDP sensitivity. Furthermore, we have recently found that the effect of ATP7A on drug resistance is not limited to CDDP. Using an ex vivo drug sensitivity assay, the histoculture drug response assay (HDRA), the expression of ATP7A in human surgically resected colon cancer cells correlated with sensitivity to 7-ethyl-10-hydroxy-camptothecin (SN-38). ATP7Aoverexpressing cells are resistant to many anticancer drugs including SN-38, 7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin (CPT-11), vincristine, paclitaxel, etoposide, doxorubicin (Dox), and mitoxantron. The mechanism by which ATP7A and copper metabolism modulate drug transport appears to involve modulation of drug cellular localization via modulation of the vesicle transport system. In ATP7A overexpressing cells, Dox accumulates in the Golgi apparatus. In contrast, in the parental cells, Dox is localized in the nuclei, where the target molecules of Dox, topoisomerase II and DNA, are found. Disruption of the intracellular vesicle transport system with monensin, a Na+/H+ ionophore, induced the relocalization of Dox from the Golgi apparatus to the nuclei in the ATP7A overexpressing cells. These data suggested that ATP7A-related drug transport is dependent on the vesicle transport system. Thus copper transport systems play important roles in drug transport as well as in copper metabolism. Components of copper metabolism are therefore likely to include target molecules for the modulation of drug potency of not only anti-cancer agents but also of other drugs. Keywords: Copper transport, CTR1, ATP7A, ATP7B, CDDP, multidrug resistance, vesicle transport" @default.
• W2098778934 created "2016-06-24" @default.
• W2098778934 creator A5006713800 @default.
• W2098778934 creator A5009725414 @default.
• W2098778934 creator A5017035937 @default.
• W2098778934 creator A5022255783 @default.
• W2098778934 creator A5067387824 @default.
• W2098778934 date "2008-12-01" @default.
• W2098778934 modified "2023-10-18" @default.
• W2098778934 title "Copper Transport Systems are Involved in Multidrug Resistance and Drug Transport" @default.
• W2098778934 doi "https://doi.org/10.2174/092986708786848479" @default.
• W2098778934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19075668" @default.
• W2098778934 hasPublicationYear "2008" @default.
• W2098778934 type Work @default.
• W2098778934 sameAs 2098778934 @default.
• W2098778934 citedByCount "50" @default.
• W2098778934 countsByYear W20987789342012 @default.
• W2098778934 countsByYear W20987789342013 @default.
• W2098778934 countsByYear W20987789342014 @default.
• W2098778934 countsByYear W20987789342015 @default.
• W2098778934 countsByYear W20987789342016 @default.
• W2098778934 countsByYear W20987789342017 @default.
• W2098778934 countsByYear W20987789342018 @default.
• W2098778934 countsByYear W20987789342019 @default.
• W2098778934 countsByYear W20987789342020 @default.
• W2098778934 countsByYear W20987789342021 @default.
• W2098778934 countsByYear W20987789342022 @default.
• W2098778934 countsByYear W20987789342023 @default.
• W2098778934 crossrefType "journal-article" @default.
• W2098778934 hasAuthorship W2098778934A5006713800 @default.
• W2098778934 hasAuthorship W2098778934A5009725414 @default.
• W2098778934 hasAuthorship W2098778934A5017035937 @default.
• W2098778934 hasAuthorship W2098778934A5022255783 @default.
• W2098778934 hasAuthorship W2098778934A5067387824 @default.
• W2098778934 hasConcept C104317684 @default.
• W2098778934 hasConcept C142724271 @default.
• W2098778934 hasConcept C149011108 @default.
• W2098778934 hasConcept C178790620 @default.
• W2098778934 hasConcept C185592680 @default.
• W2098778934 hasConcept C200082930 @default.
• W2098778934 hasConcept C2775838275 @default.
• W2098778934 hasConcept C2775962898 @default.
• W2098778934 hasConcept C2776151105 @default.
• W2098778934 hasConcept C2777581567 @default.
• W2098778934 hasConcept C2779736553 @default.
• W2098778934 hasConcept C2991729501 @default.
• W2098778934 hasConcept C544778455 @default.
• W2098778934 hasConcept C55493867 @default.
• W2098778934 hasConcept C57581600 @default.
• W2098778934 hasConcept C71924100 @default.
• W2098778934 hasConcept C86803240 @default.
• W2098778934 hasConcept C95444343 @default.
• W2098778934 hasConcept C98274493 @default.
• W2098778934 hasConceptScore W2098778934C104317684 @default.
• W2098778934 hasConceptScore W2098778934C142724271 @default.
• W2098778934 hasConceptScore W2098778934C149011108 @default.
• W2098778934 hasConceptScore W2098778934C178790620 @default.
• W2098778934 hasConceptScore W2098778934C185592680 @default.
• W2098778934 hasConceptScore W2098778934C200082930 @default.
• W2098778934 hasConceptScore W2098778934C2775838275 @default.
• W2098778934 hasConceptScore W2098778934C2775962898 @default.
• W2098778934 hasConceptScore W2098778934C2776151105 @default.
• W2098778934 hasConceptScore W2098778934C2777581567 @default.
• W2098778934 hasConceptScore W2098778934C2779736553 @default.
• W2098778934 hasConceptScore W2098778934C2991729501 @default.
• W2098778934 hasConceptScore W2098778934C544778455 @default.
• W2098778934 hasConceptScore W2098778934C55493867 @default.
• W2098778934 hasConceptScore W2098778934C57581600 @default.
• W2098778934 hasConceptScore W2098778934C71924100 @default.
• W2098778934 hasConceptScore W2098778934C86803240 @default.
• W2098778934 hasConceptScore W2098778934C95444343 @default.
• W2098778934 hasConceptScore W2098778934C98274493 @default.
• W2098778934 hasIssue "30" @default.
• W2098778934 hasLocation W20987789341 @default.
• W2098778934 hasLocation W20987789342 @default.
• W2098778934 hasOpenAccess W2098778934 @default.
• W2098778934 hasPrimaryLocation W20987789341 @default.
• W2098778934 hasRelatedWork W1519459752 @default.
• W2098778934 hasRelatedWork W1884328895 @default.
• W2098778934 hasRelatedWork W1989407846 @default.
• W2098778934 hasRelatedWork W2026712007 @default.
• W2098778934 hasRelatedWork W2098778934 @default.
• W2098778934 hasRelatedWork W2122373849 @default.
• W2098778934 hasRelatedWork W2123685783 @default.
• W2098778934 hasRelatedWork W2902383603 @default.
• W2098778934 hasRelatedWork W4236242442 @default.
• W2098778934 hasRelatedWork W4386702590 @default.
• W2098778934 hasVolume "15" @default.
• W2098778934 isParatext "false" @default.
• W2098778934 isRetracted "false" @default.
• W2098778934 magId "2098778934" @default.
• W2098778934 workType "article" @default.