FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098804546> ?p ?o ?g. }

• W2098804546 endingPage "H1796" @default.
• W2098804546 startingPage "H1789" @default.
• W2098804546 abstract "l-Serine administration reduces mean arterial pressure (MAP) in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats rendered hypertensive by chronic oral treatment with the nitric oxide synthase inhibitor N ω -nitro-l-arginine methyl ester (l-NAME). To determine if the fall in MAP was due to decreases in vascular resistance or cardiac output (CO), and to record regional hemodynamic effects, we measured the distribution of fluorescent microspheres to single bolus intravenous injections of l-serine (1 mmol/kg) in 14-wk-old male WKY, SHR, and l-NAME-treated WKY rats. MAP and total peripheral resistance (TPR) were significantly higher ( P < 0.01), whereas CO was lower in l-NAME-treated WKY ( P < 0.01) and SHR ( P < 0.05). l-Serine administration led to a rapid fall in MAP (WKY 22%, l-NAME-WKY 46%, SHR 34%,) and TPR (WKY 24%, l-NAME-WKY 68%, SHR 53%), whereas CO was elevated. In WKY rats, l-serine induced an increase in blood flow only in the small intestine (53%) while it was more profound in several vascular beds of hypertensive rats [l-NAME-WKY: small intestine (238%), spleen (184%), diaphragm (85%), and liver (65%); SHR: small intestine (217%), spleen (202%), diaphragm (116%), large intestine (105%), pancreas (96%), and liver (93%)]. Pretreatment with a combination of apamin (a small calcium-activated potassium channel inhibitor) and charybdotoxin (an intermediate calcium-activated potassium channel inhibitor) abolished the l-serine-induced changes in blood flow and TPR. l-Serine acts predominantly on apamin- and charybdotoxin-sensitive potassium channels in the splanchnic circulation to increase blood flow, thereby contributing to the fall in TPR and the pronounced blood pressure-lowering effect of l-serine in hypertensive rats." @default.
• W2098804546 created "2016-06-24" @default.
• W2098804546 creator A5003838246 @default.
• W2098804546 creator A5014221820 @default.
• W2098804546 creator A5021702116 @default.
• W2098804546 creator A5026441751 @default.
• W2098804546 creator A5044330738 @default.
• W2098804546 creator A5055074393 @default.
• W2098804546 creator A5090764423 @default.
• W2098804546 date "2010-06-01" @default.
• W2098804546 modified "2023-09-27" @default.
• W2098804546 title "Decreases in splanchnic vascular resistance contribute to hypotensive effects of<scp>l</scp>-serine in hypertensive rats" @default.
• W2098804546 cites W172274380 @default.
• W2098804546 cites W1887879545 @default.
• W2098804546 cites W193145437 @default.
• W2098804546 cites W1969856812 @default.
• W2098804546 cites W1977073350 @default.
• W2098804546 cites W1984097105 @default.
• W2098804546 cites W1987556166 @default.
• W2098804546 cites W1992986490 @default.
• W2098804546 cites W2020495830 @default.
• W2098804546 cites W2020834404 @default.
• W2098804546 cites W2033930586 @default.
• W2098804546 cites W2038613674 @default.
• W2098804546 cites W2050775539 @default.
• W2098804546 cites W2085630915 @default.
• W2098804546 cites W2087187431 @default.
• W2098804546 cites W2100587643 @default.
• W2098804546 cites W2107925005 @default.
• W2098804546 cites W2110435754 @default.
• W2098804546 cites W2113587201 @default.
• W2098804546 cites W2123987363 @default.
• W2098804546 cites W2124209848 @default.
• W2098804546 cites W2132349068 @default.
• W2098804546 cites W2140724463 @default.
• W2098804546 cites W2141579920 @default.
• W2098804546 cites W2154199259 @default.
• W2098804546 cites W2163007060 @default.
• W2098804546 cites W2181273021 @default.
• W2098804546 cites W2213418952 @default.
• W2098804546 cites W2317614904 @default.
• W2098804546 cites W2333488825 @default.
• W2098804546 cites W2401332295 @default.
• W2098804546 cites W2413810802 @default.
• W2098804546 cites W2423810330 @default.
• W2098804546 doi "https://doi.org/10.1152/ajpheart.00810.2009" @default.
• W2098804546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20348218" @default.
• W2098804546 hasPublicationYear "2010" @default.
• W2098804546 type Work @default.
• W2098804546 sameAs 2098804546 @default.
• W2098804546 citedByCount "6" @default.
• W2098804546 countsByYear W20988045462012 @default.
• W2098804546 countsByYear W20988045462013 @default.
• W2098804546 countsByYear W20988045462014 @default.
• W2098804546 countsByYear W20988045462017 @default.
• W2098804546 countsByYear W20988045462022 @default.
• W2098804546 crossrefType "journal-article" @default.
• W2098804546 hasAuthorship W2098804546A5003838246 @default.
• W2098804546 hasAuthorship W2098804546A5014221820 @default.
• W2098804546 hasAuthorship W2098804546A5021702116 @default.
• W2098804546 hasAuthorship W2098804546A5026441751 @default.
• W2098804546 hasAuthorship W2098804546A5044330738 @default.
• W2098804546 hasAuthorship W2098804546A5055074393 @default.
• W2098804546 hasAuthorship W2098804546A5090764423 @default.
• W2098804546 hasConcept C120770815 @default.
• W2098804546 hasConcept C126322002 @default.
• W2098804546 hasConcept C134018914 @default.
• W2098804546 hasConcept C185592680 @default.
• W2098804546 hasConcept C2776919887 @default.
• W2098804546 hasConcept C2777882243 @default.
• W2098804546 hasConcept C2780419564 @default.
• W2098804546 hasConcept C71924100 @default.
• W2098804546 hasConcept C83743174 @default.
• W2098804546 hasConceptScore W2098804546C120770815 @default.
• W2098804546 hasConceptScore W2098804546C126322002 @default.
• W2098804546 hasConceptScore W2098804546C134018914 @default.
• W2098804546 hasConceptScore W2098804546C185592680 @default.
• W2098804546 hasConceptScore W2098804546C2776919887 @default.
• W2098804546 hasConceptScore W2098804546C2777882243 @default.
• W2098804546 hasConceptScore W2098804546C2780419564 @default.
• W2098804546 hasConceptScore W2098804546C71924100 @default.
• W2098804546 hasConceptScore W2098804546C83743174 @default.
• W2098804546 hasIssue "6" @default.
• W2098804546 hasLocation W20988045461 @default.
• W2098804546 hasLocation W20988045462 @default.
• W2098804546 hasOpenAccess W2098804546 @default.
• W2098804546 hasPrimaryLocation W20988045461 @default.
• W2098804546 hasRelatedWork W13527351 @default.
• W2098804546 hasRelatedWork W2038331527 @default.
• W2098804546 hasRelatedWork W2055235783 @default.
• W2098804546 hasRelatedWork W2068271157 @default.
• W2098804546 hasRelatedWork W2085464702 @default.
• W2098804546 hasRelatedWork W2197852183 @default.
• W2098804546 hasRelatedWork W2412848702 @default.
• W2098804546 hasRelatedWork W2417190956 @default.
• W2098804546 hasRelatedWork W2748952813 @default.
• W2098804546 hasRelatedWork W588813213 @default.
• W2098804546 hasVolume "298" @default.

• next