FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098814720> ?p ?o ?g. }

• W2098814720 endingPage "H2378" @default.
• W2098814720 startingPage "H2371" @default.
• W2098814720 abstract "We recently demonstrated that mice deficient in endothelial nitric oxide (NO) synthase (eNOS) have congenital septal defects and postnatal heart failure. However, the mechanisms by which eNOS affects heart development are not clear. We hypothesized that deficiency in eNOS impairs myocardial angiogenesis. Myocardial capillary densities were measured morphometrically in neonatal mouse hearts. In vitro tube formation on Matrigel was investigated in cardiac endothelial cells. In vivo myocardial angiogenesis was performed by implanting Matrigel in the left ventricular myocardium. Myocardial capillary densities and VEGF mRNA expression were decreased in neonatal eNOS(-/-) compared with neonatal wild-type mice (P < 0.01). Furthermore, in vitro tube formation from cardiac endothelial cells and in vivo myocardial angiogenesis were attenuated in eNOS(-/-) compared with wild-type mice (P < 0.01). In vitro tube formation was inhibited by N(G)-nitro-l-arginine methyl ester in wild-type mice and restored by a NO donor, diethylenetriamine-NO, in eNOS(-/-) mice (P < 0.05). In conclusion, deficiency in eNOS decreases VEGF expression and impairs myocardial angiogenesis and capillary development. Decreased myocardial angiogenesis may contribute to cardiac abnormalities during heart development in eNOS(-/-) mice." @default.
• W2098814720 created "2016-06-24" @default.
• W2098814720 creator A5017480363 @default.
• W2098814720 creator A5058987902 @default.
• W2098814720 creator A5075524395 @default.
• W2098814720 date "2002-12-01" @default.
• W2098814720 modified "2023-10-16" @default.
• W2098814720 title "Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis" @default.
• W2098814720 cites W1679229092 @default.
• W2098814720 cites W1864236397 @default.
• W2098814720 cites W1968719918 @default.
• W2098814720 cites W1985112972 @default.
• W2098814720 cites W1985712533 @default.
• W2098814720 cites W1989049255 @default.
• W2098814720 cites W1999296939 @default.
• W2098814720 cites W2023175037 @default.
• W2098814720 cites W2025245180 @default.
• W2098814720 cites W2030679007 @default.
• W2098814720 cites W2036021417 @default.
• W2098814720 cites W2036209107 @default.
• W2098814720 cites W2041034845 @default.
• W2098814720 cites W2054241501 @default.
• W2098814720 cites W2079416469 @default.
• W2098814720 cites W2086719224 @default.
• W2098814720 cites W2087221897 @default.
• W2098814720 cites W2113589294 @default.
• W2098814720 cites W2118414375 @default.
• W2098814720 cites W2126618234 @default.
• W2098814720 cites W2133353133 @default.
• W2098814720 cites W2138454311 @default.
• W2098814720 cites W2153608588 @default.
• W2098814720 cites W2153726078 @default.
• W2098814720 cites W2157520030 @default.
• W2098814720 cites W2159938243 @default.
• W2098814720 cites W2164531601 @default.
• W2098814720 cites W2169642130 @default.
• W2098814720 cites W2318172046 @default.
• W2098814720 cites W2338553549 @default.
• W2098814720 cites W2070082147 @default.
• W2098814720 doi "https://doi.org/10.1152/ajpheart.00383.2002" @default.
• W2098814720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12388304" @default.
• W2098814720 hasPublicationYear "2002" @default.
• W2098814720 type Work @default.
• W2098814720 sameAs 2098814720 @default.
• W2098814720 citedByCount "102" @default.
• W2098814720 countsByYear W20988147202012 @default.
• W2098814720 countsByYear W20988147202013 @default.
• W2098814720 countsByYear W20988147202014 @default.
• W2098814720 countsByYear W20988147202015 @default.
• W2098814720 countsByYear W20988147202016 @default.
• W2098814720 countsByYear W20988147202017 @default.
• W2098814720 countsByYear W20988147202019 @default.
• W2098814720 countsByYear W20988147202020 @default.
• W2098814720 countsByYear W20988147202021 @default.
• W2098814720 countsByYear W20988147202023 @default.
• W2098814720 crossrefType "journal-article" @default.
• W2098814720 hasAuthorship W2098814720A5017480363 @default.
• W2098814720 hasAuthorship W2098814720A5058987902 @default.
• W2098814720 hasAuthorship W2098814720A5075524395 @default.
• W2098814720 hasConcept C126322002 @default.
• W2098814720 hasConcept C134018914 @default.
• W2098814720 hasConcept C150903083 @default.
• W2098814720 hasConcept C185592680 @default.
• W2098814720 hasConcept C207001950 @default.
• W2098814720 hasConcept C2777622882 @default.
• W2098814720 hasConcept C2778271429 @default.
• W2098814720 hasConcept C2778326061 @default.
• W2098814720 hasConcept C2778608917 @default.
• W2098814720 hasConcept C2780394083 @default.
• W2098814720 hasConcept C519581460 @default.
• W2098814720 hasConcept C71924100 @default.
• W2098814720 hasConcept C86803240 @default.
• W2098814720 hasConceptScore W2098814720C126322002 @default.
• W2098814720 hasConceptScore W2098814720C134018914 @default.
• W2098814720 hasConceptScore W2098814720C150903083 @default.
• W2098814720 hasConceptScore W2098814720C185592680 @default.
• W2098814720 hasConceptScore W2098814720C207001950 @default.
• W2098814720 hasConceptScore W2098814720C2777622882 @default.
• W2098814720 hasConceptScore W2098814720C2778271429 @default.
• W2098814720 hasConceptScore W2098814720C2778326061 @default.
• W2098814720 hasConceptScore W2098814720C2778608917 @default.
• W2098814720 hasConceptScore W2098814720C2780394083 @default.
• W2098814720 hasConceptScore W2098814720C519581460 @default.
• W2098814720 hasConceptScore W2098814720C71924100 @default.
• W2098814720 hasConceptScore W2098814720C86803240 @default.
• W2098814720 hasIssue "6" @default.
• W2098814720 hasLocation W20988147201 @default.
• W2098814720 hasLocation W20988147202 @default.
• W2098814720 hasOpenAccess W2098814720 @default.
• W2098814720 hasPrimaryLocation W20988147201 @default.
• W2098814720 hasRelatedWork W2058103173 @default.
• W2098814720 hasRelatedWork W2059935052 @default.
• W2098814720 hasRelatedWork W2114204950 @default.
• W2098814720 hasRelatedWork W2157520030 @default.
• W2098814720 hasRelatedWork W2349030099 @default.
• W2098814720 hasRelatedWork W2403779027 @default.
• W2098814720 hasRelatedWork W2561578967 @default.
• W2098814720 hasRelatedWork W3031948910 @default.

• next