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• W2098829275 abstract "Chronic neck pain is one of the most common musculoskeletal disorders in the US. Although biomechanical and clinical studies have implicated the facet joint as a primary source of neck pain, specific cellular mechanisms still remain speculative. The purpose of this study was to investigate whether a mediator (activating transcription factor; 4ATF4) of the integrated stress response (ISR) is involved in facet-mediated pain. Holtzman rats underwent C6/C7 facet joint loading that produces either painful (n=16) or nonpainful (n=8) responses. A sham group (n=9) was also included as surgical controls. Behavioral sensitivity was measured and the C6 dorsal root ganglia (DRGs) were harvested on day 7 to evaluate the total and neuronal ATF4 expression. In separate groups, an intra-articular ketorolac injection was administered either immediately (D0 ketorolac) or 1 day (D1 ketorolac) after painful facet joint loading. Allodynia was measured at days 1 and 7 after injury to assess the effects on behavioral responses. ATF4 and BiP (an indicator of ISR activation) were separately quantified at day 7. Facet joint loading sufficient to elicit behavioral hypersensitivity produced a threefold increase in total and neuronal ATF4 expression in the DRG. After ketorolac treatment at the time of injury, ATF4 expression was significantly (P<0.01) reduced despite not producing any attenuation of behavioral responses. Interestingly, ketorolac treatment at day 1 significantly (P<0.001) alleviated behavioral sensitivity at day 7, but did not modify ATF4 expression. BiP expression was unchanged after either intervention time. Results suggest that ATF4-dependent activation of the ISR does not directly contribute to persistent pain, but it may sensitize neurons responsible for pain initiation. These behavioral and immunohistochemical findings imply that facet-mediated pain may be sustained through other pathways of the ISR." @default.
• W2098829275 created "2016-06-24" @default.
• W2098829275 creator A5016042596 @default.
• W2098829275 creator A5040997688 @default.
• W2098829275 creator A5051613807 @default.
• W2098829275 creator A5067062682 @default.
• W2098829275 date "2011-10-01" @default.
• W2098829275 modified "2023-10-04" @default.
• W2098829275 title "Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction" @default.
• W2098829275 cites W1494869083 @default.
• W2098829275 cites W1571249042 @default.
• W2098829275 cites W1966608076 @default.
• W2098829275 cites W1966623888 @default.
• W2098829275 cites W1969649449 @default.
• W2098829275 cites W1970174046 @default.
• W2098829275 cites W1978999653 @default.
• W2098829275 cites W1979193480 @default.
• W2098829275 cites W1983800020 @default.
• W2098829275 cites W1988120375 @default.
• W2098829275 cites W1994932727 @default.
• W2098829275 cites W1995578467 @default.
• W2098829275 cites W1997831000 @default.
• W2098829275 cites W1998452222 @default.
• W2098829275 cites W1998750525 @default.
• W2098829275 cites W2002165197 @default.
• W2098829275 cites W2003434610 @default.
• W2098829275 cites W2003884564 @default.
• W2098829275 cites W2004557173 @default.
• W2098829275 cites W2012050679 @default.
• W2098829275 cites W2012347444 @default.
• W2098829275 cites W2013966205 @default.
• W2098829275 cites W2014036182 @default.
• W2098829275 cites W2018324188 @default.
• W2098829275 cites W2019764823 @default.
• W2098829275 cites W2026377831 @default.
• W2098829275 cites W2027821655 @default.
• W2098829275 cites W2029639369 @default.
• W2098829275 cites W2033803319 @default.
• W2098829275 cites W2034214469 @default.
• W2098829275 cites W2035838553 @default.
• W2098829275 cites W2037617187 @default.
• W2098829275 cites W2038037509 @default.
• W2098829275 cites W2040580773 @default.
• W2098829275 cites W2040952209 @default.
• W2098829275 cites W2042199574 @default.
• W2098829275 cites W2042399623 @default.
• W2098829275 cites W2043950293 @default.
• W2098829275 cites W2047010161 @default.
• W2098829275 cites W2048551040 @default.
• W2098829275 cites W2048705028 @default.
• W2098829275 cites W2048829454 @default.
• W2098829275 cites W2049340310 @default.
• W2098829275 cites W2050584349 @default.
• W2098829275 cites W2050822001 @default.
• W2098829275 cites W2052091537 @default.
• W2098829275 cites W2052304591 @default.
• W2098829275 cites W2058663392 @default.
• W2098829275 cites W2060730194 @default.
• W2098829275 cites W2062272207 @default.
• W2098829275 cites W2063229389 @default.
• W2098829275 cites W2069216668 @default.
• W2098829275 cites W2071868735 @default.
• W2098829275 cites W2074944397 @default.
• W2098829275 cites W2076107364 @default.
• W2098829275 cites W2080097408 @default.
• W2098829275 cites W2085444051 @default.
• W2098829275 cites W2087454739 @default.
• W2098829275 cites W2088179197 @default.
• W2098829275 cites W2089880580 @default.
• W2098829275 cites W2093718785 @default.
• W2098829275 cites W2102909249 @default.
• W2098829275 cites W2106443798 @default.
• W2098829275 cites W2114078791 @default.
• W2098829275 cites W2114224169 @default.
• W2098829275 cites W2116114885 @default.
• W2098829275 cites W2116343997 @default.
• W2098829275 cites W2116380331 @default.
• W2098829275 cites W2120653342 @default.
• W2098829275 cites W2123258170 @default.
• W2098829275 cites W2123534594 @default.
• W2098829275 cites W2125871871 @default.
• W2098829275 cites W2127848114 @default.
• W2098829275 cites W2131632095 @default.
• W2098829275 cites W2136729555 @default.
• W2098829275 cites W2137662702 @default.
• W2098829275 cites W2159466552 @default.
• W2098829275 cites W2161250027 @default.
• W2098829275 cites W2163345943 @default.
• W2098829275 cites W2166342883 @default.
• W2098829275 cites W2168459166 @default.
• W2098829275 cites W2172201406 @default.
• W2098829275 cites W2323420455 @default.
• W2098829275 cites W2991476156 @default.
• W2098829275 doi "https://doi.org/10.1016/j.neuroscience.2011.07.059" @default.
• W2098829275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3171593" @default.
• W2098829275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21821103" @default.
• W2098829275 hasPublicationYear "2011" @default.
• W2098829275 type Work @default.

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