FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098831599> ?p ?o ?g. }

• W2098831599 endingPage "309" @default.
• W2098831599 startingPage "301" @default.
• W2098831599 abstract "Multi-drug resistance due in part to membrane pumps such as P-glycoprotein (Pgp) is a major clinical problem in human cancers. We tested the ability of liposomally-encapsulated daunorubicin (DR) to overcome resistance to this drug. A widely used breast carcinoma cell line originally selected for resistance in doxorubicin (MCF7ADR) was 4-fold resistant to DR compared to the parent MCF7 cells (IC50 79 nM vs. 20 nM). Ovarian carcinoma cells (SKOV3) were made resistant by retroviral transduction of MDR1 cDNA and selection in vinblastine. The resulting SKOV3MGP1 cells were 130-fold resistant to DR compared to parent cells (IC50 5700 nM vs. 44 nM). Small-cell lung carcinoma cells (H69VP) originally selected for resistance to etoposide were 6-fold resistant to DR compared to H69 parent cells (IC50 180 nM vs. 30 nM). In all three cases, encapsulation of DR in liposomes as Daunoxome (Gilead) did not change the IC50 of parent cells relative to free DR. However, liposomal DR overcame resistance in MCF7ADR breast carcinoma cells (IC50 20 nM), SKOV3MGP1 ovarian carcinoma cells (IC50 237 nM) and H69VP small-cell lung carcinoma cells (IC50 27 nM). Empty liposomes did not affect the IC50 for free DR in the three resistant cell lines, nor did empty liposomes affect the IC50 for other drugs that are part of the multi-drug resistance phenotype (etoposide, vincristine) in lung carcinoma cells. These data indicate the possible value of liposomal DR in overcoming Pgp-mediated drug resistance in human cancer." @default.
• W2098831599 created "2016-06-24" @default.
• W2098831599 creator A5008329336 @default.
• W2098831599 creator A5024556072 @default.
• W2098831599 creator A5037412259 @default.
• W2098831599 date "2002-01-01" @default.
• W2098831599 modified "2023-10-15" @default.
• W2098831599 title "LIPOSOMAL DAUNORUBICIN OVERCOMES DRUG RESISTANCE IN HUMAN BREAST, OVARIAN AND LUNG CARCINOMA CELLS" @default.
• W2098831599 cites W1660272883 @default.
• W2098831599 cites W1706395004 @default.
• W2098831599 cites W1862306466 @default.
• W2098831599 cites W1966410823 @default.
• W2098831599 cites W1974485358 @default.
• W2098831599 cites W1977925611 @default.
• W2098831599 cites W1981735895 @default.
• W2098831599 cites W1987235854 @default.
• W2098831599 cites W1994880640 @default.
• W2098831599 cites W1994960331 @default.
• W2098831599 cites W1999651010 @default.
• W2098831599 cites W2014155634 @default.
• W2098831599 cites W2033969577 @default.
• W2098831599 cites W2034371227 @default.
• W2098831599 cites W2052366563 @default.
• W2098831599 cites W2081742328 @default.
• W2098831599 cites W2103970111 @default.
• W2098831599 cites W2133408654 @default.
• W2098831599 cites W2153331027 @default.
• W2098831599 cites W2158157639 @default.
• W2098831599 cites W2160684474 @default.
• W2098831599 cites W2202035925 @default.
• W2098831599 cites W336484898 @default.
• W2098831599 doi "https://doi.org/10.1081/lpr-120016196" @default.
• W2098831599 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12519627" @default.
• W2098831599 hasPublicationYear "2002" @default.
• W2098831599 type Work @default.
• W2098831599 sameAs 2098831599 @default.
• W2098831599 citedByCount "59" @default.
• W2098831599 countsByYear W20988315992012 @default.
• W2098831599 countsByYear W20988315992013 @default.
• W2098831599 countsByYear W20988315992014 @default.
• W2098831599 countsByYear W20988315992015 @default.
• W2098831599 countsByYear W20988315992016 @default.
• W2098831599 countsByYear W20988315992017 @default.
• W2098831599 countsByYear W20988315992018 @default.
• W2098831599 countsByYear W20988315992019 @default.
• W2098831599 countsByYear W20988315992020 @default.
• W2098831599 countsByYear W20988315992021 @default.
• W2098831599 countsByYear W20988315992022 @default.
• W2098831599 countsByYear W20988315992023 @default.
• W2098831599 crossrefType "journal-article" @default.
• W2098831599 hasAuthorship W2098831599A5008329336 @default.
• W2098831599 hasAuthorship W2098831599A5024556072 @default.
• W2098831599 hasAuthorship W2098831599A5037412259 @default.
• W2098831599 hasConcept C114851261 @default.
• W2098831599 hasConcept C121608353 @default.
• W2098831599 hasConcept C126322002 @default.
• W2098831599 hasConcept C133936738 @default.
• W2098831599 hasConcept C185154212 @default.
• W2098831599 hasConcept C2776694085 @default.
• W2098831599 hasConcept C2777752497 @default.
• W2098831599 hasConcept C2778119113 @default.
• W2098831599 hasConcept C2778707650 @default.
• W2098831599 hasConcept C2780427987 @default.
• W2098831599 hasConcept C2781021840 @default.
• W2098831599 hasConcept C2781303535 @default.
• W2098831599 hasConcept C3018521938 @default.
• W2098831599 hasConcept C3019054536 @default.
• W2098831599 hasConcept C502942594 @default.
• W2098831599 hasConcept C530470458 @default.
• W2098831599 hasConcept C54355233 @default.
• W2098831599 hasConcept C55493867 @default.
• W2098831599 hasConcept C71924100 @default.
• W2098831599 hasConcept C81885089 @default.
• W2098831599 hasConcept C86803240 @default.
• W2098831599 hasConcept C89423630 @default.
• W2098831599 hasConcept C98274493 @default.
• W2098831599 hasConceptScore W2098831599C114851261 @default.
• W2098831599 hasConceptScore W2098831599C121608353 @default.
• W2098831599 hasConceptScore W2098831599C126322002 @default.
• W2098831599 hasConceptScore W2098831599C133936738 @default.
• W2098831599 hasConceptScore W2098831599C185154212 @default.
• W2098831599 hasConceptScore W2098831599C2776694085 @default.
• W2098831599 hasConceptScore W2098831599C2777752497 @default.
• W2098831599 hasConceptScore W2098831599C2778119113 @default.
• W2098831599 hasConceptScore W2098831599C2778707650 @default.
• W2098831599 hasConceptScore W2098831599C2780427987 @default.
• W2098831599 hasConceptScore W2098831599C2781021840 @default.
• W2098831599 hasConceptScore W2098831599C2781303535 @default.
• W2098831599 hasConceptScore W2098831599C3018521938 @default.
• W2098831599 hasConceptScore W2098831599C3019054536 @default.
• W2098831599 hasConceptScore W2098831599C502942594 @default.
• W2098831599 hasConceptScore W2098831599C530470458 @default.
• W2098831599 hasConceptScore W2098831599C54355233 @default.
• W2098831599 hasConceptScore W2098831599C55493867 @default.
• W2098831599 hasConceptScore W2098831599C71924100 @default.
• W2098831599 hasConceptScore W2098831599C81885089 @default.
• W2098831599 hasConceptScore W2098831599C86803240 @default.
• W2098831599 hasConceptScore W2098831599C89423630 @default.

• next