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• W2098834645 abstract "Organ-specific adhesion molecules expressed by vascular endothelial cells have been implicated in the arrest of blood-borne cancer cells in selective, secondary sites. A lung-specific endothelial cell adhesion molecule (Lu-ECAM-1) localized on endothelia of distinct branches of lung blood vessels has been purified by immunoaffinity chromatography from detergent extracts of lung matrix-modulated endothelial cells using monoclonal antibody (mAb) 6D3. It has a molecular mass of 90 kDa and promotes the selective attachment of lung-metastatic B16 melanoma cells. Corresponding with their metastatic performance, B16-F10 tumor cells selected for higher lung colonization bind to Lu-ECAM-1 in significantly higher numbers than their low lung metastatic counterpart B16-F0. Binding of B16-F0 and B16-F10 is reduced with mAb 6D3 to slightly lower levels than B16-F0 bound to Lu-ECAM-1. mAb 6D3 injected into C57BL/6 mice 1 hr prior to an i.v. challenge with B16-F10 causes a 90% reduction in the number of lung colonies compared with animals injected with control mAb (6D8 or 3C6). Lu-ECAM-1 neither binds nor effects metastasis of other lung-colonizing tumor cells (e.g., KLN205). Thus, site-specific metastasis of tumor cells is regulated by similar mechanisms as the homing of lymphocytes--namely, by the ability of blood-borne cancer cells to recognize and adhere to distinct endothelial cell adhesion molecules." @default.
• W2098834645 created "2016-06-24" @default.
• W2098834645 creator A5001110412 @default.
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• W2098834645 date "1991-11-01" @default.
• W2098834645 modified "2023-09-26" @default.
• W2098834645 title "Mediation of lung metastasis of murine melanomas by a lung-specific endothelial cell adhesion molecule." @default.
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• W2098834645 doi "https://doi.org/10.1073/pnas.88.21.9568" @default.
• W2098834645 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/52759" @default.
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