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- W2098840785 abstract "The effects of elevated temperatures upon protein biosynthesis were determined in L5178Y murine leukemic lymphoblasts. The rate of protein synthesis was inhibited proportionately to the increase in temperature. Efforts were made to determine the mechanism of heat inactivation of protein synthesis by studying the requirements for recovery of activity after the cells were returned to 37°C. The ability of actinomycin to block the recovery process suggests that elevated temperatures destroy or inactivate a species of RNA required for protein synthesis. Loss of RNA during heating of the cells is apparently at least partially dependent on protein synthesis, since the presence of cycloheximide during heat shock, is capable of ameliorating the effects of short duration heat treatment." @default.
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- W2098840785 date "1974-12-01" @default.
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- W2098840785 title "Effect of hyperthermia on protein biosynthesis in L5178Y murine leukemic lymphoblasts" @default.
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- W2098840785 doi "https://doi.org/10.1002/jcp.1040840305" @default.
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