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• W2098855274 abstract "Activators of innate immunity may have the potential to combat a broad range of infectious agents. We report that treatment with bacterial flagellin prevented rotavirus (RV) infection in mice and cured chronically RV-infected mice. Protection was independent of adaptive immunity and interferon (IFN, type I and II) and required flagellin receptors Toll-like receptor 5 (TLR5) and NOD-like receptor C4 (NLRC4). Flagellin-induced activation of TLR5 on dendritic cells elicited production of the cytokine interleukin-22 (IL-22), which induced a protective gene expression program in intestinal epithelial cells. Flagellin also induced NLRC4-dependent production of IL-18 and immediate elimination of RV-infected cells. Administration of IL-22 and IL-18 to mice fully recapitulated the capacity of flagellin to prevent or eliminate RV infection and thus holds promise as a broad-spectrum antiviral agent." @default.
• W2098855274 created "2016-06-24" @default.
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• W2098855274 date "2014-11-14" @default.
• W2098855274 modified "2023-10-18" @default.
• W2098855274 title "Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18" @default.
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• W2098855274 doi "https://doi.org/10.1126/science.1256999" @default.
• W2098855274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4788408" @default.
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• W2098855274 hasPublicationYear "2014" @default.
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