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- W2098875989 abstract "Background Hepatosplenic T-cell lymphoma (HSTL) is a rare extranodal and systemic lymphoma derived from cytotoxic T cells usually of γδ T cell receptor type. It is characterized by primary extranodal disease with typical sinusoidal infiltration of liver, spleen, and bone marrow by medium-sized lymphoid cells. Case Report A 29-year-old man, with no significant prior medical history, presented with fever and massive splenomegaly. A diagnosis of HSTL was established by histologic examination and immunohistochemistry. Staging workup demonstrated bone marrow involvement by lymphoma. In addition, the patient was found to have hepatitis B infection. The association of these 2 entities has been described rarely. Conclusions Hepatosplenic T-cell lymphoma is a distinct T cell lymphoma associated with an aggressive clinical course, a poor response to conventional treatment, and an exceedingly high mortality rate. An association of HSTL with hepatitis B as seen in the present case is exceedingly rare, with few cases reported in the literature." @default.
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- W2098875989 date "2016-11-01" @default.
- W2098875989 modified "2023-09-27" @default.
- W2098875989 title "Hepatosplenic T-Cell Lymphoma with Coexistent Hepatitis B Infection: A Rare Clinicopathologic Entity" @default.
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- W2098875989 doi "https://doi.org/10.5301/tj.5000445" @default.
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