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• W2098877886 abstract "Summary Stable RNA maturation is a key process in the generation of functional RNAs , and failure to correctly process these RNAs can lead to their elimination through quality control mechanisms. Studies of the maturation pathways of ribosomal RNA and transfer RNA in B acillus subtilis showed they were radically different from E scherichia coli and led to the identification of new B . subtilis ‐specific enzymes. We noticed that, despite their important roles in translation, a number of B . subtilis small stable RNAs still did not have characterised maturation pathways, notably the tmRNA , involved in ribosome rescue, and the RNase P RNA , involved in tRNA maturation. Here, we show that tmRNA is matured by RNase P and RNase Z at its 5′ and 3′ extremities, respectively, whereas the RNase P RNA is matured on its 3′ side by RNase Y . Recent evidence that several RNases are not essential in B . subtilis prompted us to revisit maturation of the scRNA , a component of the signal recognition particle involved in co‐translational insertion of specific proteins into the membrane. We show that RNase Y is also involved in 3′ processing of scRNA . Lastly, we identified some of the enzymes involved in the turnover of these three stable RNAs ." @default.
• W2098877886 created "2016-06-24" @default.
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• W2098877886 date "2014-12-19" @default.
• W2098877886 modified "2023-10-03" @default.
• W2098877886 title "Small stable RNA maturation and turnover in<i>B</i><i>acillus subtilis</i>" @default.
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• W2098877886 doi "https://doi.org/10.1111/mmi.12863" @default.
• W2098877886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4364036" @default.
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• W2098877886 hasPublicationYear "2014" @default.
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