FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098889163> ?p ?o ?g. }

• W2098889163 endingPage "11955" @default.
• W2098889163 startingPage "11942" @default.
• W2098889163 abstract "Natriuretic peptides (NPs) control natriuresis and normalize changes in blood pressure. Recent studies suggest that NPs are also involved in the regulation of pain sensitivity, although the underlying mechanisms remain essentially unknown. Many biological effects of NPs are mediated by guanylate cyclase (GC)-coupled NP receptors, NPR-A and NPR-B, whereas the third NP receptor, NPR-C, lacks the GC kinase domain and acts as the NP clearance receptor. In addition, NPR-C can couple to specific Gα i –Gβγ-mediated intracellular signaling cascades in numerous cell types. We found that NPR-C is coexpressed in transient receptor potential vanilloid-1 (TRPV1)-expressing mouse dorsal root ganglia (DRG) neurons. NPR-C can be coimmunoprecipitated with Gα i , and C-type natriuretic peptide (CNP) treatment induced translocation of protein kinase Cε (PKCε) to the plasma membrane of these neurons, which was inhibited by pertussis toxin pretreatment. Application of CNP potentiated capsaicin- and proton-activated TRPV1 currents in cultured mouse DRG neurons and increased their firing frequency, an effect that was absent in DRG neurons from TRPV1 −/− mice. CNP-induced sensitization of TRPV1 activity was attenuated by pretreatment of DRG neurons with the specific inhibitors of Gβγ, phospholipase C-β (PLCβ), or PKC, but not of protein kinase A, and was abolished by mutations at two PKC phosphorylation sites in TRPV1. Furthermore, CNP injection into mouse hindpaw led to the development of thermal hyperalgesia that was attenuated by administration of specific inhibitors of Gβγ or TRPV1 and was also absent in TRPV1 −/− mice. Thus, our work identifies the Gβγ–PLCβ–PKC-dependent potentiation of TRPV1 as a novel signaling cascade recruited by CNP in mouse DRG neurons that can lead to enhanced nociceptor excitability and thermal hypersensitivity." @default.
• W2098889163 created "2016-06-24" @default.
• W2098889163 creator A5001777124 @default.
• W2098889163 creator A5004330439 @default.
• W2098889163 creator A5006001351 @default.
• W2098889163 creator A5020149890 @default.
• W2098889163 creator A5032909017 @default.
• W2098889163 creator A5069825995 @default.
• W2098889163 creator A5089562312 @default.
• W2098889163 date "2012-08-29" @default.
• W2098889163 modified "2023-10-03" @default.
• W2098889163 title "The C-Type Natriuretic Peptide Induces Thermal Hyperalgesia through a Noncanonical Gβγ-dependent Modulation of TRPV1 Channel" @default.
• W2098889163 cites W1492591187 @default.
• W2098889163 cites W1509155252 @default.
• W2098889163 cites W1952328179 @default.
• W2098889163 cites W1963857381 @default.
• W2098889163 cites W1967858335 @default.
• W2098889163 cites W1968008199 @default.
• W2098889163 cites W1971754431 @default.
• W2098889163 cites W1971953711 @default.
• W2098889163 cites W1977324136 @default.
• W2098889163 cites W1984033377 @default.
• W2098889163 cites W1986235007 @default.
• W2098889163 cites W1990649212 @default.
• W2098889163 cites W1996634599 @default.
• W2098889163 cites W1997743372 @default.
• W2098889163 cites W2004801897 @default.
• W2098889163 cites W2006441426 @default.
• W2098889163 cites W2011361041 @default.
• W2098889163 cites W2012030770 @default.
• W2098889163 cites W2018543284 @default.
• W2098889163 cites W2019861198 @default.
• W2098889163 cites W2023195612 @default.
• W2098889163 cites W2039113093 @default.
• W2098889163 cites W2039522435 @default.
• W2098889163 cites W2042653860 @default.
• W2098889163 cites W2048276401 @default.
• W2098889163 cites W2049100687 @default.
• W2098889163 cites W2053682262 @default.
• W2098889163 cites W2058878920 @default.
• W2098889163 cites W2062606765 @default.
• W2098889163 cites W2063918788 @default.
• W2098889163 cites W2069918422 @default.
• W2098889163 cites W2075715972 @default.
• W2098889163 cites W2078393209 @default.
• W2098889163 cites W2078671315 @default.
• W2098889163 cites W2082400577 @default.
• W2098889163 cites W2092015036 @default.
• W2098889163 cites W2094813259 @default.
• W2098889163 cites W2095108162 @default.
• W2098889163 cites W2106701169 @default.
• W2098889163 cites W2118492208 @default.
• W2098889163 cites W2119832782 @default.
• W2098889163 cites W2122762441 @default.
• W2098889163 cites W2127070923 @default.
• W2098889163 cites W2128725121 @default.
• W2098889163 cites W2133490942 @default.
• W2098889163 cites W2142203676 @default.
• W2098889163 cites W2149855043 @default.
• W2098889163 cites W2160611045 @default.
• W2098889163 cites W2410733370 @default.
• W2098889163 cites W4246208988 @default.
• W2098889163 cites W72705582 @default.
• W2098889163 cites W1978619207 @default.
• W2098889163 doi "https://doi.org/10.1523/jneurosci.1330-12.2012" @default.
• W2098889163 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3461320" @default.
• W2098889163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22933780" @default.
• W2098889163 hasPublicationYear "2012" @default.
• W2098889163 type Work @default.
• W2098889163 sameAs 2098889163 @default.
• W2098889163 citedByCount "43" @default.
• W2098889163 countsByYear W20988891632012 @default.
• W2098889163 countsByYear W20988891632013 @default.
• W2098889163 countsByYear W20988891632014 @default.
• W2098889163 countsByYear W20988891632015 @default.
• W2098889163 countsByYear W20988891632016 @default.
• W2098889163 countsByYear W20988891632017 @default.
• W2098889163 countsByYear W20988891632018 @default.
• W2098889163 countsByYear W20988891632019 @default.
• W2098889163 countsByYear W20988891632020 @default.
• W2098889163 countsByYear W20988891632021 @default.
• W2098889163 countsByYear W20988891632022 @default.
• W2098889163 countsByYear W20988891632023 @default.
• W2098889163 crossrefType "journal-article" @default.
• W2098889163 hasAuthorship W2098889163A5001777124 @default.
• W2098889163 hasAuthorship W2098889163A5004330439 @default.
• W2098889163 hasAuthorship W2098889163A5006001351 @default.
• W2098889163 hasAuthorship W2098889163A5020149890 @default.
• W2098889163 hasAuthorship W2098889163A5032909017 @default.
• W2098889163 hasAuthorship W2098889163A5069825995 @default.
• W2098889163 hasAuthorship W2098889163A5089562312 @default.
• W2098889163 hasBestOaLocation W20988891631 @default.
• W2098889163 hasConcept C11960822 @default.
• W2098889163 hasConcept C126322002 @default.
• W2098889163 hasConcept C134018914 @default.
• W2098889163 hasConcept C155164980 @default.
• W2098889163 hasConcept C160145004 @default.
• W2098889163 hasConcept C170493617 @default.

• next