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- W2098918424 endingPage "1442" @default.
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- W2098918424 abstract "A number of discoveries have clarified the molecular mechanism of apoptosis, thus clarifying the link between apoptosis and therapeutic outcome. Even though apoptosis is thought to play a major role in anticancer therapy, the clinical relevance of induction of apoptosis remains uncertain, particularly in solid tumors. Induction of apoptosis by anticancer agents has been shown to correlate with tumor response, however, nonapoptotic forms of cell death, such as autophagy and extrinsic senescence, have also been shown to contribute to the overall tumor response. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, necrosis, and senescence; the mechanism of cell death depends on the magnitude of DNA damage following exposure to various concentrations of anticancer agents. Apoptosis-resistant cells and transduction pathways which inhibit apoptosis can induce nonapoptotic mechanisms of cell death and senescence, thereby preserving the antitumor effect of some anticancer agents. Heterogeneic antitumor responses include various cell types of cell death, depending on the degree of cellular or DNA damage incurred by cancer cells. As a new therapeutic strategy, alternative types of cell death might be exploited to control and eradicate cancer cells. This review discusses the clinical significance of apoptosis, as well as the potential contribution of other types of cell death to overall tumor sensitivity in the hopes that new therapeutic strategies might follow." @default.
- W2098918424 created "2016-06-24" @default.
- W2098918424 creator A5035696772 @default.
- W2098918424 creator A5042448872 @default.
- W2098918424 creator A5086049881 @default.
- W2098918424 date "2006-11-14" @default.
- W2098918424 modified "2023-09-30" @default.
- W2098918424 title "The role of apoptosis in cancer cell survival and therapeutic outcome" @default.
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