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- W2098932790 abstract "Organic mercurials inhibit mitochondrial glutamine metabolism in vitro while metabolic acidosis, a condition in which the predominant renal fuel is glutamine, potentiates mercurial diuresis. The following studies were undertaken to determine whether potentiation of diuresis reflects mercurial inhibition of glutamine utilization.(1) All three mercurials employed (mersalyl, chlormerodrin, and p-chloromercuribenzoate) are diuretics in the rat and this effect was potentiated by NH 4 Cl.(2) Despite reabsorbing less sodium, mercurial-treated rats had lower kidney ATP content (4.35 ± 0.26 and 3.85 ± 0.43 μmol/g dry weight (mercurial plus NH 4 Cl)) than did controls (4.95 ± 0.31 and 4.87 ± 0.39 μmol/g dry weight (NH 4 Cl)).(3) Isolated kidneys from NH 4 Cl and NH 4 Cl plus mercurial treated rats were perfused with 1 mML-[U- 14 C]glutamine to determine rates of extraction and oxidation. Mercurial-treated acidotic rat kidneys had a reduced rate of glutamine uptake (40.8 ± 7.4 vs. 64.8 ± 5.8 μmol/h. per kidney), a diminished rate of glutamine conversion to CO 2 (14.8 ± 3.6 vs. 26.4 ± 5.2 μmol/h per kidney), and a reduction in glucose production (16 ± 5 vs. 27 ± 4 μmol/h per kidney). These results are consistent with an effect of organic mercurials upon glutamine utilization, limiting ATP availability, and thereby reducing tubular active sodium reabsorption." @default.
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- W2098932790 date "1979-03-01" @default.
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- W2098932790 title "Organic mercurial diuresis: Inhibition of glutamine utilization in the acidotic rat" @default.
- W2098932790 doi "https://doi.org/10.1139/y79-035" @default.
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