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- W2098940854 abstract "Themodulation ofautophagyisnowrecognizedasoneofthehallmarksof cancercells. Dependingonthecontextand the type of cancer, autophagy may suppress tumor growth or may allow cancer cells to overcome metabolic stress and the cytotoxicity of chemotherapy. Recent studies have shed light on the role of autophagy in normal stem cells and in cancer stem cells(CSC).TheCSCconcepthasbeenacompellingbutcontroversialideaformanyyears.Recentlyseveralindependentgroups reportedtheinvivoexistenceofCSCsinbrain,intestinal,andskintumors.SpecifictargetingofCSCsmayimprovetheefficacyof cancer therapy. In this review, we will first summarize briefly our current understanding of the CSC concept, regulation of tumor heterogeneity, and CSC plasticity. We will then provide an update on the role of autophagy and signaling pathways in CSC maintenance and plasticity and, finally, will discuss the potential of targeting pathways involved in autophagy in CSCs for treatment of cancer." @default.
- W2098940854 created "2016-06-24" @default.
- W2098940854 creator A5051700932 @default.
- W2098940854 creator A5056243768 @default.
- W2098940854 creator A5086145027 @default.
- W2098940854 date "2014-01-01" @default.
- W2098940854 modified "2023-10-14" @default.
- W2098940854 title "Cancer stem cells and autophagy: Facts and Perspectives" @default.
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