FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098947992> ?p ?o ?g. }

• W2098947992 abstract "We recently showed that whereas inhibition of PI3K/akt or JAK/STAT pathway promoted retinal ganglion cell (RGC) survival after optic nerve (ON) injury in Fischer 344 (F344) rats, the same inhibition resulted in aggravated RGC loss after acute intraocular pressure (IOP) elevation in Sprague Dawley (SPD) rats. In addition, the responses of macrophages to ON injury and acute IOP elevation were different between F344 and Lewis rats, i.e., different autoimmune profiles. Using an acute IOP elevation paradigm in this study, we investigated 1) whether autoimmune background influences PI3K/akt and JAK/STAT functions by examining the effect of PI3K/akt and JAK/STAT pathway inhibition on RGC survival in F344 and Lewis rats, and 2) whether differential actions of macrophages occur in PI3K/akt and JAK/STAT pathways-dependent modulation of RGC survival. IOP elevation was performed at 110 mmHg for 2 hours. PI3K/akt and JAK/STAT pathway inhibitors were applied intravitreally to block their respective pathway signaling transduction. Because macrophage invasion was seen in the eye after the pathway inhibition, to examine the role of these pathways independent of macrophages, macrophages in the retina were removed by intravitreal application of clodronate liposomes. Viable RGCs were retrogradely labelled by FluoroGold 40 hours before animal sacrifice.Similar to what was previously observed, significantly more RGCs were lost in Lewis than F344 rats 3 weeks after acute IOP elevation. As in SPD rats, inhibition of the PI3K/akt or JAK/STAT pathway increased the loss of RGCs in both F344 and Lewis rats. Removal of macrophages in the eye by clodronate liposomes reduced RGC loss due to pathway inhibition in both strains.This study demonstrates that following acute IOP elevation 1) PI3K/akt and JAK/STAT pathways mediate RGC survival in both F344 and Lewis rats, 2) autoimmune responses do not influence the functions of these two pathways, and 3) PI3K/akt and JAK/STAT pathway inhibition-dependent activation of macrophages is detrimental to RGCs." @default.
• W2098947992 created "2016-06-24" @default.
• W2098947992 creator A5019685354 @default.
• W2098947992 creator A5026906414 @default.
• W2098947992 creator A5031685579 @default.
• W2098947992 creator A5056678009 @default.
• W2098947992 creator A5079003683 @default.
• W2098947992 date "2008-08-11" @default.
• W2098947992 modified "2023-10-15" @default.
• W2098947992 title "Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds" @default.
• W2098947992 cites W1563169973 @default.
• W2098947992 cites W1651927573 @default.
• W2098947992 cites W1675594938 @default.
• W2098947992 cites W1868514048 @default.
• W2098947992 cites W1906407967 @default.
• W2098947992 cites W1966086081 @default.
• W2098947992 cites W1969737809 @default.
• W2098947992 cites W1982422365 @default.
• W2098947992 cites W1985633670 @default.
• W2098947992 cites W1992674549 @default.
• W2098947992 cites W1993677761 @default.
• W2098947992 cites W2001928921 @default.
• W2098947992 cites W2012240654 @default.
• W2098947992 cites W2016781954 @default.
• W2098947992 cites W2020148917 @default.
• W2098947992 cites W2021340181 @default.
• W2098947992 cites W2021385876 @default.
• W2098947992 cites W2025008185 @default.
• W2098947992 cites W2031441113 @default.
• W2098947992 cites W2038521086 @default.
• W2098947992 cites W2038716662 @default.
• W2098947992 cites W2052990948 @default.
• W2098947992 cites W2065601509 @default.
• W2098947992 cites W2071421185 @default.
• W2098947992 cites W2080683593 @default.
• W2098947992 cites W2084574028 @default.
• W2098947992 cites W2093601466 @default.
• W2098947992 cites W2095816451 @default.
• W2098947992 cites W2101741807 @default.
• W2098947992 cites W2107589629 @default.
• W2098947992 cites W2112361941 @default.
• W2098947992 cites W2118270120 @default.
• W2098947992 cites W2123347673 @default.
• W2098947992 cites W2130729942 @default.
• W2098947992 cites W2135551394 @default.
• W2098947992 cites W2146299385 @default.
• W2098947992 cites W2147114673 @default.
• W2098947992 cites W2151363901 @default.
• W2098947992 cites W4242117937 @default.
• W2098947992 cites W4249670700 @default.
• W2098947992 cites W4252049794 @default.
• W2098947992 doi "https://doi.org/10.1186/1471-2202-9-78" @default.
• W2098947992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2533008" @default.
• W2098947992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18691439" @default.
• W2098947992 hasPublicationYear "2008" @default.
• W2098947992 type Work @default.
• W2098947992 sameAs 2098947992 @default.
• W2098947992 citedByCount "17" @default.
• W2098947992 countsByYear W20989479922012 @default.
• W2098947992 countsByYear W20989479922013 @default.
• W2098947992 countsByYear W20989479922014 @default.
• W2098947992 countsByYear W20989479922015 @default.
• W2098947992 countsByYear W20989479922016 @default.
• W2098947992 countsByYear W20989479922017 @default.
• W2098947992 countsByYear W20989479922018 @default.
• W2098947992 countsByYear W20989479922021 @default.
• W2098947992 countsByYear W20989479922022 @default.
• W2098947992 countsByYear W20989479922023 @default.
• W2098947992 crossrefType "journal-article" @default.
• W2098947992 hasAuthorship W2098947992A5019685354 @default.
• W2098947992 hasAuthorship W2098947992A5026906414 @default.
• W2098947992 hasAuthorship W2098947992A5031685579 @default.
• W2098947992 hasAuthorship W2098947992A5056678009 @default.
• W2098947992 hasAuthorship W2098947992A5079003683 @default.
• W2098947992 hasBestOaLocation W20989479921 @default.
• W2098947992 hasConcept C118487528 @default.
• W2098947992 hasConcept C126322002 @default.
• W2098947992 hasConcept C134018914 @default.
• W2098947992 hasConcept C157333092 @default.
• W2098947992 hasConcept C170493617 @default.
• W2098947992 hasConcept C2777624874 @default.
• W2098947992 hasConcept C2778277574 @default.
• W2098947992 hasConcept C2778923194 @default.
• W2098947992 hasConcept C2780837183 @default.
• W2098947992 hasConcept C2781092963 @default.
• W2098947992 hasConcept C42362537 @default.
• W2098947992 hasConcept C62478195 @default.
• W2098947992 hasConcept C71924100 @default.
• W2098947992 hasConcept C75217442 @default.
• W2098947992 hasConcept C86554907 @default.
• W2098947992 hasConcept C86803240 @default.
• W2098947992 hasConcept C95444343 @default.
• W2098947992 hasConceptScore W2098947992C118487528 @default.
• W2098947992 hasConceptScore W2098947992C126322002 @default.
• W2098947992 hasConceptScore W2098947992C134018914 @default.
• W2098947992 hasConceptScore W2098947992C157333092 @default.
• W2098947992 hasConceptScore W2098947992C170493617 @default.
• W2098947992 hasConceptScore W2098947992C2777624874 @default.
• W2098947992 hasConceptScore W2098947992C2778277574 @default.
• W2098947992 hasConceptScore W2098947992C2778923194 @default.

• next