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• W2098977319 abstract "We asked whether the central effects of fatiguing locomotor muscle fatigue exert an inhibitory influence on central motor drive to regulate the total degree of peripheral fatigue development. Eight cyclists performed constant‐workload prefatigue trials (a) to exhaustion (83% of peak power output ( W peak ), 10 ± 1 min; PFT 83% ), and (b) for an identical duration but at 67% W peak (PFT 67% ). Exercise‐induced peripheral quadriceps fatigue was assessed via changes in potentiated quadriceps twitch force (Δ Q tw,pot ) from pre‐ to post‐exercise in response to supra‐maximal femoral nerve stimulation (Δ Q tw,pot ). On different days, each subject randomly performed three 5 km time trials (TTs). First, subjects repeated PFT 83% and the TT was started 4 min later with a known level of pre‐existing locomotor muscle fatigue (Δ Q tw,pot −36%) (PFT 83% ‐TT). Second, subjects repeated PFT 67% and the TT was started 4 min later with a known level of pre‐existing locomotor muscle fatigue (Δ Q tw,pot −20%) (PFT 67% ‐TT). Finally, a control TT was performed without any pre‐existing level of fatigue. Central neural drive during the three TTs was estimated via quadriceps EMG. Increases in pre‐existing locomotor muscle fatigue from control TT to PFT 83% ‐TT resulted in significant dose‐dependent changes in central motor drive (−23%), power output (−14%), and performance time (+6%) during the TTs. However, the magnitude of locomotor muscle fatigue following various TTs was not different (Δ Q tw,pot of −35 to −37%, P = 0.35). We suggest that feedback from fatiguing muscle plays an important role in the determination of central motor drive and force output, so that the development of peripheral muscle fatigue is confined to a certain level." @default.
• W2098977319 created "2016-06-24" @default.
• W2098977319 creator A5011098520 @default.
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• W2098977319 date "2008-01-01" @default.
• W2098977319 modified "2023-10-16" @default.
• W2098977319 title "Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance" @default.
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• W2098977319 doi "https://doi.org/10.1113/jphysiol.2007.141838" @default.
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