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- W2098980122 abstract "Deletions on chromosome 8p are common in human tumors, suggesting that one or more tumor suppressor genes reside in this region. Deleted in Liver Cancer 1 ( DLC1 ) encodes a Rho-GTPase activating protein and is a candidate 8p tumor suppressor. We show that DLC1 knockdown cooperates with Myc to promote hepatocellular carcinoma in mice, and that reintroduction of wild-type DLC1 into hepatoma cells with low DLC1 levels suppresses tumor growth in situ. Cells with reduced DLC1 protein contain increased GTP-bound RhoA, and enforced expression a constitutively activated RhoA allele mimics DLC1 loss in promoting hepatocellular carcinogenesis. Conversely, down-regulation of RhoA selectively inhibits tumor growth of hepatoma cells with disabled DLC1. Our data validate DLC1 as a potent tumor suppressor gene and suggest that its loss creates a dependence on the RhoA pathway that may be targeted therapeutically." @default.
- W2098980122 created "2016-06-24" @default.
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- W2098980122 date "2008-06-01" @default.
- W2098980122 modified "2023-10-18" @default.
- W2098980122 title "<i>DLC1</i> is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma" @default.
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- W2098980122 doi "https://doi.org/10.1101/gad.1672608" @default.
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