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• W2098981650 abstract "Heterotopic ossification (HO) and fatty infiltration (FI) often occur in diseased skeletal muscle and have been previously described in various animal models of Duchenne muscular dystrophy (DMD); however, the pathological mechanisms remain largely unknown. Dystrophin-deficient mdx mice and dystrophin/utrophin double-knockout (dKO) mice are mouse models of DMD; however, mdx mice display a strong muscle regeneration capacity, while dKO mice exhibit a much more severe phenotype, which is similar to patients with DMD. Our results revealed that more extensive HO, but not FI, occurred in the skeletal muscle of dKO mice versus mdx mice, and RhoA activation specifically occurred at the sites of HO. Moreover, the gene expression of RhoA, BMPs, and several inflammatory factors were significantly up-regulated in muscle stem cells isolated from dKO mice; while inactivation of RhoA in the cells with RhoA/ROCK inhibitor Y-27632 led to reduced osteogenic potential and improved myogenic potential. Finally, inactivation of RhoA signaling in the dKO mice with Y-27632 improved muscle regeneration and reduced the expression of BMPs, inflammation, HO, and intramyocellular lipid accumulation in both skeletal and cardiac muscle. Our results revealed that RhoA represents a major molecular switch in the regulation of HO and muscle regeneration in dystrophic skeletal muscle of mice.— Mu, X., Usas, A., Tang, Y., Lu, A., Wang, B., Weiss, K., Huard, J., RhoA mediates defective stem cell function and heterotopic ossification in dystrophic muscle of mice. FASEB J. 27, 3619–3631 (2013). www.fasebj.org" @default.
• W2098981650 created "2016-06-24" @default.
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• W2098981650 date "2013-05-23" @default.
• W2098981650 modified "2023-10-16" @default.
• W2098981650 title "RhoA mediates defective stem cell function and heterotopic ossification in dystrophic muscle of mice" @default.
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• W2098981650 cites W1854064841 @default.
• W2098981650 cites W1910650341 @default.
• W2098981650 cites W1964935932 @default.
• W2098981650 cites W1965328032 @default.
• W2098981650 cites W1970719549 @default.
• W2098981650 cites W1976986089 @default.
• W2098981650 cites W1979615123 @default.
• W2098981650 cites W1981169627 @default.
• W2098981650 cites W1981920590 @default.
• W2098981650 cites W1986088843 @default.
• W2098981650 cites W1986514886 @default.
• W2098981650 cites W1987980762 @default.
• W2098981650 cites W1989838345 @default.
• W2098981650 cites W1993419506 @default.
• W2098981650 cites W1996563680 @default.
• W2098981650 cites W1999902156 @default.
• W2098981650 cites W2000982151 @default.
• W2098981650 cites W2004107033 @default.
• W2098981650 cites W2008527819 @default.
• W2098981650 cites W2010353145 @default.
• W2098981650 cites W2019563312 @default.
• W2098981650 cites W2022851337 @default.
• W2098981650 cites W2023698258 @default.
• W2098981650 cites W2026192447 @default.
• W2098981650 cites W2026880091 @default.
• W2098981650 cites W2032946279 @default.
• W2098981650 cites W2035184766 @default.
• W2098981650 cites W2036522702 @default.
• W2098981650 cites W2051741101 @default.
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• W2098981650 cites W2068644492 @default.
• W2098981650 cites W2069233373 @default.
• W2098981650 cites W2070081094 @default.
• W2098981650 cites W2070242218 @default.
• W2098981650 cites W2070831457 @default.
• W2098981650 cites W2071035219 @default.
• W2098981650 cites W2072951915 @default.
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• W2098981650 doi "https://doi.org/10.1096/fj.13-233460" @default.
• W2098981650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4046169" @default.
• W2098981650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23704088" @default.
• W2098981650 hasPublicationYear "2013" @default.
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