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• W2098981666 abstract "Dynamic contrast enhanced MRI (DCE-MRI) has utility for improving clinical diagnoses of solid tumors, and for evaluating the early responses of anti-angiogenic chemotherapies. The Reference Region Model (RRM) can improve the clinical implementation of DCE-MRI by substituting the contrast enhancement of muscle for the Arterial Input Function that is used in traditional DCE-MRI methodologies. The RRM is typically fitted to experimental results with a non-linear least squares algorithm. This report demonstrates that this algorithm produces inaccurate and imprecise results when DCE-MRI results have low SNR or slow temporal resolution. To overcome this limitation, a linear least-squares algorithm has been derived for the Reference Region Model. This new algorithm improves accuracy and precision of fitting the Reference Region Model to DCE-MRI results, especially for voxel-wise analyses. This linear algorithm is insensitive to injection speeds, and has 300- to 8000-fold faster calculation speed relative to the non-linear algorithm. The linear algorithm produces more accurate results for over a wider range of permeabilities and blood volumes of tumor vasculature. This new algorithm, termed the Linear Reference Region Model, has strong potential to improve clinical DCE-MRI evaluations." @default.
• W2098981666 created "2016-06-24" @default.
• W2098981666 creator A5053582890 @default.
• W2098981666 creator A5063962241 @default.
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• W2098981666 date "2013-05-01" @default.
• W2098981666 modified "2023-10-17" @default.
• W2098981666 title "A linear algorithm of the reference region model for DCE-MRI is robust and relaxes requirements for temporal resolution" @default.
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• W2098981666 doi "https://doi.org/10.1016/j.mri.2012.10.008" @default.
• W2098981666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3639320" @default.
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• W2098981666 hasPublicationYear "2013" @default.
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