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• W2098986904 abstract "A brief high-frequency burst of action potentials results in a sustained force increase in skeletal muscle. The present study investigates whether this force potentiation is the result of a sustained increase of the free myoplasmic [Ca2+] ([Ca2+]i). Single fibers from mouse flexor brevis muscles were stimulated with three impulses at 150 Hz (triplet) at the start of a 350-ms tetanus or in the middle of a 700-ms tetanus; the stimulation frequency of the rest of the tetanus ranged from 20 to 60 Hz. After the triplet, force was significantly (P < 0.05) increased between 17 and 20% when the triplet was given at the start of the tetanus and between 5 and 18% when the triplet was given in the middle (n = 7). However, during this potentiation, [Ca2+]i was not consistently increased. Hence, the increased force following a high-frequency burst is likely due to changes in the myofibrillar properties." @default.
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• W2098986904 date "2002-07-01" @default.
• W2098986904 modified "2023-10-06" @default.
• W2098986904 title "Prolonged force increase following a high-frequency burst is not due to a sustained elevation of [Ca²⁺]_i" @default.
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• W2098986904 doi "https://doi.org/10.1152/ajpcell.00416.2001" @default.
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