FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2098998099> ?p ?o ?g. }

• W2098998099 endingPage "2684" @default.
• W2098998099 startingPage "2677" @default.
• W2098998099 abstract "Background: Duodenal cancer is the leading cause of cancer death in familial adenomatous polyposis after colorectal cancer. The lifetime risk for developing duodenal cancer is 4% to 10%. Current treatment guidelines recommend endoscopic surveillance with a prophylactic pancreaticoduodenectomy in advanced duodenal polyposis, defined using the Spigelman staging system. Because no clinical trials have assessed this recommendation, a modeling approach was used to evaluate the cost-effectiveness of various treatment strategies.Methods: A Markov model was constructed to estimate the life expectancy and cost of three different strategies: pancreaticoduodenectomy at Spigelman stage III, pancreaticoduodenectomy at Spigelman stage IV, and pancreaticoduodenectomy at cancer diagnosis. A cohort of 30-year-old familial adenomatous polyposis patients with total colectomies was simulated until age 80. The analysis was from a societal perspective. Extensive sensitivity analysis was performed to assess the impact of model uncertainty on results.Results: At all stages of polyposis and all ages <80 years, prophylactic surgery at Spigelman stage IV resulted in the greatest life expectancy. Surgery at stage IV was more effective and more expensive than surgery at cancer diagnosis, with an incremental cost of $3,200 per quality-adjusted life year gained. Surgery at stage III was not a viable option. The results were robust to wide variation in model parameters but were sensitive to the post-pancreaticoduodenectomy quality of life score.Conclusions: Prophylactic pancreaticoduodenectomy at stage IV duodenal polyposis in familial adenomatous polyposis is a cost-effective approach that results in greater life expectancy than surgery at either stage III or cancer diagnosis. (Cancer Epidemiol Biomarkers Prev 2009;18(10):2677–84)" @default.
• W2098998099 created "2016-06-24" @default.
• W2098998099 creator A5009216690 @default.
• W2098998099 creator A5016099408 @default.
• W2098998099 creator A5043501566 @default.
• W2098998099 creator A5055200350 @default.
• W2098998099 creator A5069564081 @default.
• W2098998099 creator A5086897381 @default.
• W2098998099 date "2009-09-29" @default.
• W2098998099 modified "2023-10-14" @default.
• W2098998099 title "Cost-Effectiveness of Prophylactic Surgery for Duodenal Cancer in Familial Adenomatous Polyposis" @default.
• W2098998099 cites W1481572195 @default.
• W2098998099 cites W1969821527 @default.
• W2098998099 cites W1973198263 @default.
• W2098998099 cites W1977416980 @default.
• W2098998099 cites W1979871017 @default.
• W2098998099 cites W1980169946 @default.
• W2098998099 cites W1982464261 @default.
• W2098998099 cites W1983127735 @default.
• W2098998099 cites W1987768599 @default.
• W2098998099 cites W1992977427 @default.
• W2098998099 cites W1996772303 @default.
• W2098998099 cites W1999404209 @default.
• W2098998099 cites W1999596214 @default.
• W2098998099 cites W2000444608 @default.
• W2098998099 cites W2006216218 @default.
• W2098998099 cites W2007430187 @default.
• W2098998099 cites W2008965970 @default.
• W2098998099 cites W2033068174 @default.
• W2098998099 cites W2034862688 @default.
• W2098998099 cites W2043951092 @default.
• W2098998099 cites W2044796990 @default.
• W2098998099 cites W2045217572 @default.
• W2098998099 cites W2046511786 @default.
• W2098998099 cites W2051527870 @default.
• W2098998099 cites W2053445880 @default.
• W2098998099 cites W2061075674 @default.
• W2098998099 cites W2061472128 @default.
• W2098998099 cites W2063891559 @default.
• W2098998099 cites W2065697922 @default.
• W2098998099 cites W2068318740 @default.
• W2098998099 cites W2070256294 @default.
• W2098998099 cites W2076864099 @default.
• W2098998099 cites W2080696794 @default.
• W2098998099 cites W2081615556 @default.
• W2098998099 cites W2083902873 @default.
• W2098998099 cites W2084807026 @default.
• W2098998099 cites W2090101639 @default.
• W2098998099 cites W2094145886 @default.
• W2098998099 cites W2100284762 @default.
• W2098998099 cites W2103635373 @default.
• W2098998099 cites W2104138316 @default.
• W2098998099 cites W2104831554 @default.
• W2098998099 cites W2114532114 @default.
• W2098998099 cites W2114998652 @default.
• W2098998099 cites W2133441192 @default.
• W2098998099 cites W2137167848 @default.
• W2098998099 cites W2146114745 @default.
• W2098998099 cites W2161793046 @default.
• W2098998099 cites W2166535194 @default.
• W2098998099 cites W24151698 @default.
• W2098998099 cites W310192158 @default.
• W2098998099 cites W3203717762 @default.
• W2098998099 doi "https://doi.org/10.1158/1055-9965.epi-09-0153" @default.
• W2098998099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2759853" @default.
• W2098998099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19789369" @default.
• W2098998099 hasPublicationYear "2009" @default.
• W2098998099 type Work @default.
• W2098998099 sameAs 2098998099 @default.
• W2098998099 citedByCount "2" @default.
• W2098998099 countsByYear W20989980992012 @default.
• W2098998099 countsByYear W20989980992021 @default.
• W2098998099 crossrefType "journal-article" @default.
• W2098998099 hasAuthorship W2098998099A5009216690 @default.
• W2098998099 hasAuthorship W2098998099A5016099408 @default.
• W2098998099 hasAuthorship W2098998099A5043501566 @default.
• W2098998099 hasAuthorship W2098998099A5055200350 @default.
• W2098998099 hasAuthorship W2098998099A5069564081 @default.
• W2098998099 hasAuthorship W2098998099A5086897381 @default.
• W2098998099 hasBestOaLocation W20989980991 @default.
• W2098998099 hasConcept C121608353 @default.
• W2098998099 hasConcept C126322002 @default.
• W2098998099 hasConcept C133925201 @default.
• W2098998099 hasConcept C141071460 @default.
• W2098998099 hasConcept C146357865 @default.
• W2098998099 hasConcept C151730666 @default.
• W2098998099 hasConcept C159110408 @default.
• W2098998099 hasConcept C159110652 @default.
• W2098998099 hasConcept C2778975757 @default.
• W2098998099 hasConcept C2779951463 @default.
• W2098998099 hasConcept C2780814781 @default.
• W2098998099 hasConcept C2781357019 @default.
• W2098998099 hasConcept C2908647359 @default.
• W2098998099 hasConcept C2910584544 @default.
• W2098998099 hasConcept C526805850 @default.
• W2098998099 hasConcept C530470458 @default.
• W2098998099 hasConcept C542804219 @default.
• W2098998099 hasConcept C61434518 @default.

• next