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• W2099003301 abstract "<h3>Abstract</h3> <b>Objectives</b> To determine the benefits and risks of a non-steroidal anti-inflammatory drug (NSAID) as prophylaxis for ectopic bone formation in patients undergoing total hip replacement (or revision) surgery. <b>Design</b> Double blind randomised placebo controlled clinical trial, stratified by treatment site and surgery (primary or revision). <b>Setting</b> 20 orthopaedic surgery centres in Australia and New Zealand. <b>Participants</b> 902 patients undergoing elective primary or revision total hip replacement surgery. <b>Intervention</b> 14 days9 treatment with ibuprofen (1200 mg daily) or matching placebo started within 24 hours of surgery. <b>Main outcome measures</b> Changes in self reported hip pain and physical function 6 to 12 months after surgery (Western Ontario and McMaster University Arthritis index). <b>Results</b> There were no significant differences between the groups for improvements in hip pain (mean difference −0.1, 95% confidence interval −0.4 to 0.2, P = 0.6) or physical function (−0.1, −0.4 to 0.2, P = 0.5), despite a decreased risk of ectopic bone formation (relative risk 0.69, 0.56 to 0.83) associated with ibuprofen. There was a significantly increased risk of major bleeding complications in the ibuprofen group during the admission period (2.09, 1.00 to 4.39). <b>Conclusions</b> These data do not support the use of routine prophylaxis with NSAIDs in patients undergoing total hip replacement surgery. <b>Trial registration</b>NCT00145730[ClinicalTrials.gov]." @default.
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• W2099003301 date "2006-08-02" @default.
• W2099003301 modified "2023-09-25" @default.
• W2099003301 title "Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial" @default.
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• W2099003301 doi "https://doi.org/10.1136/bmj.38925.471146.4f" @default.
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