FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099008462> ?p ?o ?g. }

• W2099008462 endingPage "112" @default.
• W2099008462 startingPage "101" @default.
• W2099008462 abstract "Bisphenol A (BPA), known as an environmental endocrine disruptor, is widely used as a plasticizer. This study aims to investigate whether exposure in utero to BPA alters the architecture, proliferative index, and genomic signature of the rat mammary gland during critical stages of development. Pregnant rats were gavaged with 25 μg BPA/kg body weight (BW; low-dose group) or 250 μg BPA/kg BW (high-dose group) from day 10 post-conception to delivery. Female litters were euthanized at 21, 35, 50, and 100 days, and mammary glands were collected. Analysis of gland morphology was performed from whole-mounted mammary tissue, while proliferative index was determined by detection of bromodeoxyuridine incorporation in the epithelial cells. Genomic profiles were obtained by microarray analysis, and some genes were validated by real-time RT-PCR. BPA exposure induced changes in the mammary gland that were time and dose specific. High-dose exposure resulted in architectural modifications, mainly in the number of undifferentiated epithelial structures of the breast tissue. Proliferative index did not show remarkable differences by the effect of BPA. Low and high doses of BPA changed the gene expression signature of the mammary gland following a different fashion: low dose had the highest effect by 50 days, while high dose had a highest influence on gene expression by 100 days. Both doses presented a significant cluster of up-modulated genes related to the immune system at the age of maximal changes. Moreover, high-dose exposure induced changes in genes related to differentiation suggesting alterations in the normal development of the gland. The increase of undifferentiated structures and the changes in the gene expression profile at different ages suggest that prenatal exposure to BPA can affect the susceptibility of the mammary gland to transformation." @default.
• W2099008462 created "2016-06-24" @default.
• W2099008462 creator A5024124503 @default.
• W2099008462 creator A5035198130 @default.
• W2099008462 creator A5046511241 @default.
• W2099008462 creator A5054880138 @default.
• W2099008462 creator A5081696479 @default.
• W2099008462 creator A5085451281 @default.
• W2099008462 date "2007-10-10" @default.
• W2099008462 modified "2023-09-27" @default.
• W2099008462 title "Effect of prenatal exposure to the endocrine disruptor bisphenol A on mammary gland morphology and gene expression signature" @default.
• W2099008462 cites W147319812 @default.
• W2099008462 cites W1520840150 @default.
• W2099008462 cites W1557591071 @default.
• W2099008462 cites W1823225455 @default.
• W2099008462 cites W1864091535 @default.
• W2099008462 cites W194362540 @default.
• W2099008462 cites W1958254026 @default.
• W2099008462 cites W1958327198 @default.
• W2099008462 cites W1964155369 @default.
• W2099008462 cites W1965377429 @default.
• W2099008462 cites W1972426382 @default.
• W2099008462 cites W1976531107 @default.
• W2099008462 cites W1979829167 @default.
• W2099008462 cites W1990979633 @default.
• W2099008462 cites W1993352525 @default.
• W2099008462 cites W1993744150 @default.
• W2099008462 cites W1994987017 @default.
• W2099008462 cites W1999662564 @default.
• W2099008462 cites W2001956694 @default.
• W2099008462 cites W2002135196 @default.
• W2099008462 cites W2005674560 @default.
• W2099008462 cites W2006664266 @default.
• W2099008462 cites W2009094206 @default.
• W2099008462 cites W2012169853 @default.
• W2099008462 cites W2015233760 @default.
• W2099008462 cites W2025509528 @default.
• W2099008462 cites W2027109773 @default.
• W2099008462 cites W2036136192 @default.
• W2099008462 cites W2036849754 @default.
• W2099008462 cites W2037728383 @default.
• W2099008462 cites W2039711181 @default.
• W2099008462 cites W2041247730 @default.
• W2099008462 cites W2045696513 @default.
• W2099008462 cites W2046117633 @default.
• W2099008462 cites W2047741256 @default.
• W2099008462 cites W2048667586 @default.
• W2099008462 cites W2052450630 @default.
• W2099008462 cites W2053759647 @default.
• W2099008462 cites W2057598257 @default.
• W2099008462 cites W2057755903 @default.
• W2099008462 cites W2059780003 @default.
• W2099008462 cites W2062745595 @default.
• W2099008462 cites W2062847019 @default.
• W2099008462 cites W2065956796 @default.
• W2099008462 cites W2068687971 @default.
• W2099008462 cites W2071176161 @default.
• W2099008462 cites W2072544254 @default.
• W2099008462 cites W2077391745 @default.
• W2099008462 cites W2078264080 @default.
• W2099008462 cites W2081015547 @default.
• W2099008462 cites W2082154152 @default.
• W2099008462 cites W2083295728 @default.
• W2099008462 cites W2088655421 @default.
• W2099008462 cites W2089519349 @default.
• W2099008462 cites W2090601295 @default.
• W2099008462 cites W2095697394 @default.
• W2099008462 cites W2100185938 @default.
• W2099008462 cites W2101336097 @default.
• W2099008462 cites W2106626003 @default.
• W2099008462 cites W2109879710 @default.
• W2099008462 cites W2110174332 @default.
• W2099008462 cites W2125147657 @default.
• W2099008462 cites W2126073113 @default.
• W2099008462 cites W2138152339 @default.
• W2099008462 cites W2144776023 @default.
• W2099008462 cites W2144861941 @default.
• W2099008462 cites W2154174669 @default.
• W2099008462 cites W2156112336 @default.
• W2099008462 cites W2162285332 @default.
• W2099008462 cites W2162772878 @default.
• W2099008462 cites W2166523972 @default.
• W2099008462 cites W2166609686 @default.
• W2099008462 cites W2166649221 @default.
• W2099008462 cites W2167505689 @default.
• W2099008462 cites W2169509620 @default.
• W2099008462 cites W2415867315 @default.
• W2099008462 cites W2418211822 @default.
• W2099008462 cites W2506607 @default.
• W2099008462 cites W29873470 @default.
• W2099008462 cites W577238039 @default.
• W2099008462 doi "https://doi.org/10.1677/joe-07-0056" @default.
• W2099008462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18180321" @default.
• W2099008462 hasPublicationYear "2007" @default.
• W2099008462 type Work @default.
• W2099008462 sameAs 2099008462 @default.
• W2099008462 citedByCount "136" @default.
• W2099008462 countsByYear W20990084622012 @default.

• next