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- W2099013587 abstract "RNA interference (RNAi) is a double-stranded (ds)RNA-inducible, sequence-specific RNA-degradation mechanism that operates as a natural antiviral system in plants and animals. Successful virus infection requires evasion or suppression of RNAi. Indeed, RNAi suppressor proteins have been identified in plant and animal viruses, although the molecular mechanism of silencing inhibition is still poorly understood. Because many RNA viruses encode dsRNA-binding proteins (dsRBPs) and as RNAi is triggered by the accumulation of dsRNAs, dsRBPs were examined to see if they inhibit RNAi. Here, it is shown that heterologous dsRBPs suppressed RNAi in plants, indicating that in natural host-virus interactions, pathogen-encoded dsRBPs could inactivate RNAi-mediated host defences." @default.
- W2099013587 created "2016-06-24" @default.
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- W2099013587 date "2003-04-01" @default.
- W2099013587 modified "2023-09-29" @default.
- W2099013587 title "Double-stranded RNA-binding proteins could suppress RNA interference-mediated antiviral defences" @default.
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- W2099013587 doi "https://doi.org/10.1099/vir.0.18987-0" @default.
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