FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099014765> ?p ?o ?g. }

• W2099014765 endingPage "2400" @default.
• W2099014765 startingPage "2391" @default.
• W2099014765 abstract "Cellular fibronectin containing extra domain A (EDA(+)-FN) is abundant in the arteries of patients with atherosclerosis. Several in vitro studies suggest that EDA(+)-FN interacts with Toll-like receptor 4 (TLR4). We tested the hypothesis that EDA(+)-FN exacerbates atherosclerosis through TLR4 in a clinically relevant model of atherosclerosis, the apolipoprotein E-deficient (Apoe(-/-)) mouse.The extent of atherosclerosis was evaluated in whole aortae and cross sections of the aortic sinus in male and female EDA(-/-)Apoe(-/-) mice (which lack EDA(+)-FN), EDA(fl/fl)Apoe(-/-) mice (which constitutively express EDA(+)-FN), and control Apoe(-/-) mice fed a high-fat Western diet for 14 weeks. Irrespective of sex, EDA(fl/fl)Apoe(-/-) mice exhibited a 2-fold increase in atherosclerotic lesions (aorta and aortic sinus) and macrophage content within plaques, whereas EDA(-/-)Apoe(-/-) mice exhibited reduced atherosclerotic lesions (P<0.05 versus Apoe(-/-), n=10-12 mice/group), although cholesterol and triglyceride levels and circulating leukocytes were similar. Genetic ablation of TLR4 partially reversed atherosclerosis exacerbation in EDA(fl/fl)Apoe(-/-) mice (P<0.05) but had no effect on atherosclerotic lesions in EDA(-/-)Apoe(-/-) mice. Purified cellular FN, which contains EDA, potentiated dose-dependent NFκB-mediated inflammation (increased phospho-NFκB p65/NFκB p65, tumor necrosis factor-α, and interleukin-1β) in bone marrow-derived macrophages from EDA(-/-)Apoe(-/-) mice but not from EDA(-/-)TLR4(-/-)Apoe(-/-) mice. Finally, using immunohistochemistry, we provide evidence for the first time that EDA(+)-FN colocalizes with macrophage TLR4 in murine aortic lesions and human coronary artery atherosclerotic plaques.Our findings reveal that TLR4 signaling contributes to EDA(+)-FN-mediated exacerbation of atherosclerosis. We suggest that EDA(+)-FN could be a therapeutic target in atherosclerosis." @default.
• W2099014765 created "2016-06-24" @default.
• W2099014765 creator A5016475396 @default.
• W2099014765 creator A5025815573 @default.
• W2099014765 creator A5040756693 @default.
• W2099014765 creator A5043719985 @default.
• W2099014765 creator A5060649979 @default.
• W2099014765 creator A5068716490 @default.
• W2099014765 creator A5070640404 @default.
• W2099014765 creator A5076952358 @default.
• W2099014765 date "2015-11-01" @default.
• W2099014765 modified "2023-09-29" @default.
• W2099014765 title "Fibronectin Splicing Variants Containing Extra Domain A Promote Atherosclerosis in Mice Through Toll-Like Receptor 4" @default.
• W2099014765 cites W132035373 @default.
• W2099014765 cites W1516434930 @default.
• W2099014765 cites W1531761590 @default.
• W2099014765 cites W1578977725 @default.
• W2099014765 cites W1748311474 @default.
• W2099014765 cites W1944346348 @default.
• W2099014765 cites W1973816138 @default.
• W2099014765 cites W1989875044 @default.
• W2099014765 cites W1991731944 @default.
• W2099014765 cites W2008960002 @default.
• W2099014765 cites W2010791052 @default.
• W2099014765 cites W2012765742 @default.
• W2099014765 cites W2018788678 @default.
• W2099014765 cites W2029180052 @default.
• W2099014765 cites W2034368164 @default.
• W2099014765 cites W2044144438 @default.
• W2099014765 cites W2050001477 @default.
• W2099014765 cites W2053984681 @default.
• W2099014765 cites W2066188919 @default.
• W2099014765 cites W2089723196 @default.
• W2099014765 cites W2102915331 @default.
• W2099014765 cites W2112541119 @default.
• W2099014765 cites W2114534122 @default.
• W2099014765 cites W2120047761 @default.
• W2099014765 cites W2120058838 @default.
• W2099014765 cites W2123832217 @default.
• W2099014765 cites W2125874167 @default.
• W2099014765 cites W2130958415 @default.
• W2099014765 cites W2137173039 @default.
• W2099014765 cites W2148038169 @default.
• W2099014765 cites W2162530232 @default.
• W2099014765 cites W2170186706 @default.
• W2099014765 cites W2172090615 @default.
• W2099014765 doi "https://doi.org/10.1161/atvbaha.115.306474" @default.
• W2099014765 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4618710" @default.
• W2099014765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26427793" @default.
• W2099014765 hasPublicationYear "2015" @default.
• W2099014765 type Work @default.
• W2099014765 sameAs 2099014765 @default.
• W2099014765 citedByCount "46" @default.
• W2099014765 countsByYear W20990147652016 @default.
• W2099014765 countsByYear W20990147652017 @default.
• W2099014765 countsByYear W20990147652018 @default.
• W2099014765 countsByYear W20990147652019 @default.
• W2099014765 countsByYear W20990147652020 @default.
• W2099014765 countsByYear W20990147652021 @default.
• W2099014765 countsByYear W20990147652022 @default.
• W2099014765 countsByYear W20990147652023 @default.
• W2099014765 crossrefType "journal-article" @default.
• W2099014765 hasAuthorship W2099014765A5016475396 @default.
• W2099014765 hasAuthorship W2099014765A5025815573 @default.
• W2099014765 hasAuthorship W2099014765A5040756693 @default.
• W2099014765 hasAuthorship W2099014765A5043719985 @default.
• W2099014765 hasAuthorship W2099014765A5060649979 @default.
• W2099014765 hasAuthorship W2099014765A5068716490 @default.
• W2099014765 hasAuthorship W2099014765A5070640404 @default.
• W2099014765 hasAuthorship W2099014765A5076952358 @default.
• W2099014765 hasBestOaLocation W20990147651 @default.
• W2099014765 hasConcept C126322002 @default.
• W2099014765 hasConcept C134018914 @default.
• W2099014765 hasConcept C203014093 @default.
• W2099014765 hasConcept C2776070231 @default.
• W2099014765 hasConcept C2776914184 @default.
• W2099014765 hasConcept C2778163477 @default.
• W2099014765 hasConcept C2779134260 @default.
• W2099014765 hasConcept C2779980429 @default.
• W2099014765 hasConcept C2780562891 @default.
• W2099014765 hasConcept C57089818 @default.
• W2099014765 hasConcept C62746215 @default.
• W2099014765 hasConcept C71924100 @default.
• W2099014765 hasConcept C86803240 @default.
• W2099014765 hasConceptScore W2099014765C126322002 @default.
• W2099014765 hasConceptScore W2099014765C134018914 @default.
• W2099014765 hasConceptScore W2099014765C203014093 @default.
• W2099014765 hasConceptScore W2099014765C2776070231 @default.
• W2099014765 hasConceptScore W2099014765C2776914184 @default.
• W2099014765 hasConceptScore W2099014765C2778163477 @default.
• W2099014765 hasConceptScore W2099014765C2779134260 @default.
• W2099014765 hasConceptScore W2099014765C2779980429 @default.
• W2099014765 hasConceptScore W2099014765C2780562891 @default.
• W2099014765 hasConceptScore W2099014765C57089818 @default.
• W2099014765 hasConceptScore W2099014765C62746215 @default.
• W2099014765 hasConceptScore W2099014765C71924100 @default.
• W2099014765 hasConceptScore W2099014765C86803240 @default.
• W2099014765 hasIssue "11" @default.

• next