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• W2099017410 abstract "Structure-guided lead optimization of recently described benzimidazolyl acetamides addressed the key liabilities of the previous lead compound 1. These efforts culminated in the discovery of 4-{(S)-2-[2-(4-chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-3-fluoro-benzoic acid 7g, a highly potent and selective FXR agonist with excellent physicochemical and ADME properties and potent lipid lowering activity after oral administration to LDL receptor deficient mice." @default.
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• W2099017410 date "2011-02-01" @default.
• W2099017410 modified "2023-09-23" @default.
• W2099017410 title "Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties" @default.
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• W2099017410 doi "https://doi.org/10.1016/j.bmcl.2010.12.123" @default.
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