FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099019657> ?p ?o ?g. }

• W2099019657 endingPage "157" @default.
• W2099019657 startingPage "145" @default.
• W2099019657 abstract "We have demonstrated previously that 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) up-regulates Fas and FasL in immune cells, although the molecular mechanisms remain unknown. We investigated the regulation of Fas or FasL promoter by TCDD in EL4 T cells using luciferase reporter constructs. We observed 20 ± 5- and 14 ± 4-fold induction of promoter activity for Fas and FasL, respectively, after TCDD exposure. The induction of luciferase was significantly reduced (2 ± 1-fold) in the presence of α-naphthoflavone, an aryl hydrocarbon receptor (AhR) antagonist. We noted the presence of a dioxin response element (DRE) and five nuclear factor-κB (NF-κB) motifs on Fas promoter, and no DRE but two NF-κB motifs on FasL promoter. When we investigated the role of DRE and NF-κB, we observed varying levels of luciferase induction (9 ± 2-fold for DRE and 8 ± 2-fold for NF-κBs of Fas promoter and 6 ± 3-fold for NF-κBs of FasL promoter). Mutations in DRE of Fas promoter or NF-κBs of FasL promoter led to decreased luciferase induction, further supporting our results. Probes for DRE or NF-κB motifs of Fas and/or FasL promoters demonstrated mobility shift in the presence of nuclear extract from TCDD-treated EL4 cells. Furthermore, we observed supershift in mobility when DRE and NF-κB probes were incubated in the presence of anti-mouse AhR, and anti-NF-κB (RelA/p65 and p50) antibodies, respectively. Administration of TCDD into mice caused significant increase in Fas and FasL transcripts in thymus and liver. These data demonstrate that TCDD regulates Fas and FasL promoters through DRE and/or NF-κB motifs via AhR." @default.
• W2099019657 created "2016-06-24" @default.
• W2099019657 creator A5036897140 @default.
• W2099019657 creator A5046315471 @default.
• W2099019657 creator A5061239650 @default.
• W2099019657 date "2006-08-29" @default.
• W2099019657 modified "2023-10-14" @default.
• W2099019657 title "Role of Dioxin Response Element and Nuclear Factor-κB Motifs in 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-dioxin-Mediated Regulation of Fas and Fas Ligand Expression" @default.
• W2099019657 cites W1498427877 @default.
• W2099019657 cites W1545429987 @default.
• W2099019657 cites W1546537221 @default.
• W2099019657 cites W1965830185 @default.
• W2099019657 cites W1969120382 @default.
• W2099019657 cites W1972394760 @default.
• W2099019657 cites W1976399964 @default.
• W2099019657 cites W1977323242 @default.
• W2099019657 cites W1978018492 @default.
• W2099019657 cites W1979787038 @default.
• W2099019657 cites W1985754063 @default.
• W2099019657 cites W1991734275 @default.
• W2099019657 cites W1991915145 @default.
• W2099019657 cites W1998573431 @default.
• W2099019657 cites W1999317280 @default.
• W2099019657 cites W2003175616 @default.
• W2099019657 cites W2040088376 @default.
• W2099019657 cites W2050725518 @default.
• W2099019657 cites W2060645387 @default.
• W2099019657 cites W2062509860 @default.
• W2099019657 cites W2062818823 @default.
• W2099019657 cites W2072095457 @default.
• W2099019657 cites W2076404616 @default.
• W2099019657 cites W2080072676 @default.
• W2099019657 cites W2083408509 @default.
• W2099019657 cites W2085755321 @default.
• W2099019657 cites W2095261778 @default.
• W2099019657 cites W2100101477 @default.
• W2099019657 cites W2114629114 @default.
• W2099019657 cites W2118655615 @default.
• W2099019657 cites W2120473115 @default.
• W2099019657 cites W2129629870 @default.
• W2099019657 cites W2132904058 @default.
• W2099019657 cites W2133972226 @default.
• W2099019657 cites W2134752031 @default.
• W2099019657 cites W2144062280 @default.
• W2099019657 cites W2145525843 @default.
• W2099019657 cites W2146909058 @default.
• W2099019657 cites W2162067613 @default.
• W2099019657 cites W2165627850 @default.
• W2099019657 cites W2176134430 @default.
• W2099019657 cites W2256830124 @default.
• W2099019657 cites W2398419231 @default.
• W2099019657 cites W5181404 @default.
• W2099019657 doi "https://doi.org/10.1124/mol.106.028365" @default.
• W2099019657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16940415" @default.
• W2099019657 hasPublicationYear "2006" @default.
• W2099019657 type Work @default.
• W2099019657 sameAs 2099019657 @default.
• W2099019657 citedByCount "57" @default.
• W2099019657 countsByYear W20990196572012 @default.
• W2099019657 countsByYear W20990196572013 @default.
• W2099019657 countsByYear W20990196572015 @default.
• W2099019657 countsByYear W20990196572017 @default.
• W2099019657 countsByYear W20990196572018 @default.
• W2099019657 countsByYear W20990196572019 @default.
• W2099019657 countsByYear W20990196572020 @default.
• W2099019657 countsByYear W20990196572021 @default.
• W2099019657 countsByYear W20990196572022 @default.
• W2099019657 countsByYear W20990196572023 @default.
• W2099019657 crossrefType "journal-article" @default.
• W2099019657 hasAuthorship W2099019657A5036897140 @default.
• W2099019657 hasAuthorship W2099019657A5046315471 @default.
• W2099019657 hasAuthorship W2099019657A5061239650 @default.
• W2099019657 hasConcept C101762097 @default.
• W2099019657 hasConcept C104317684 @default.
• W2099019657 hasConcept C111335760 @default.
• W2099019657 hasConcept C132376346 @default.
• W2099019657 hasConcept C150194340 @default.
• W2099019657 hasConcept C153911025 @default.
• W2099019657 hasConcept C161733203 @default.
• W2099019657 hasConcept C185592680 @default.
• W2099019657 hasConcept C190283241 @default.
• W2099019657 hasConcept C2777730290 @default.
• W2099019657 hasConcept C31573885 @default.
• W2099019657 hasConcept C33594762 @default.
• W2099019657 hasConcept C54009773 @default.
• W2099019657 hasConcept C55493867 @default.
• W2099019657 hasConcept C66008609 @default.
• W2099019657 hasConcept C86339819 @default.
• W2099019657 hasConcept C86803240 @default.
• W2099019657 hasConceptScore W2099019657C101762097 @default.
• W2099019657 hasConceptScore W2099019657C104317684 @default.
• W2099019657 hasConceptScore W2099019657C111335760 @default.
• W2099019657 hasConceptScore W2099019657C132376346 @default.
• W2099019657 hasConceptScore W2099019657C150194340 @default.
• W2099019657 hasConceptScore W2099019657C153911025 @default.
• W2099019657 hasConceptScore W2099019657C161733203 @default.
• W2099019657 hasConceptScore W2099019657C185592680 @default.
• W2099019657 hasConceptScore W2099019657C190283241 @default.

• next