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• W2099019825 endingPage "944" @default.
• W2099019825 startingPage "927" @default.
• W2099019825 abstract "In nearly all human cancers, the presence of lymph node (LN) metastasis increases clinical staging and portends worse prognosis (compared to patients without LN metastasis). Herein, principally reviewing experimental and clinical data related to malignant melanoma, we discuss diverse factors that are mechanistically involved in LN metastasis. We highlight recent data that link tumor microenvironment, including inflammation (at the cellular and cytokine levels) and tumor-induced lymphangiogenesis, with nodal metastasis. Many of the newly identified genes that appear to influence LN metastasis facilitate general motility, chemotactic, or invasive properties that also increase the ability of cancer cells to disseminate and survive at distant organ sites. These new biomarkers will help predict clinical outcome and point to novel future therapies in metastatic melanoma as well as other cancers." @default.
• W2099019825 created "2016-06-24" @default.
• W2099019825 creator A5032308587 @default.
• W2099019825 creator A5042995444 @default.
• W2099019825 creator A5045346465 @default.
• W2099019825 creator A5058502716 @default.
• W2099019825 date "2011-03-01" @default.
• W2099019825 modified "2023-09-26" @default.
• W2099019825 title "Inflammation and Tumor Microenvironment in Lymph Node Metastasis" @default.
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• W2099019825 doi "https://doi.org/10.3390/cancers3010927" @default.
• W2099019825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3756397" @default.
• W2099019825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24212647" @default.
• W2099019825 hasPublicationYear "2011" @default.
• W2099019825 type Work @default.

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