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• W2099019831 abstract "Summary Pregnancy-associated plasma protein A (PAPP-A) and matrix metalloproteinase 9 (MMP-9), both zinc-binding endopeptidases, are abundantly expressed in ruptured and eroded plaques in patients with acute coronary syndromes (ACS).The adhesion molecule CD-40 ligand (CD40L), expressed on activated platelets and T-lymphocytes, can activate metalloproteinases and thereby promote plaque-rupture. N-3 fatty acids, through their anti-inflammatory and anti-thrombotic properties,might reduce the levels of these proatherosclerotic markers and thereby the development of ACS. 300 patients were randomized on day4 to 6 following an acute myocardial infarction (MI) to receive either 4g of n-3 fatty acids or a similar daily dose of corn oil for at least one year.We compared levels of PAPP-A, MMP-9 and sCD-40 L at baseline and 12 months in each group, and also looked for inter-group changes. In the omega-3 group, the median level of PAPP-A rose from 0.47 mU/l to 0.56 mU/l (p < 0.001). In the same group, sCD-40 L decreased froma mean baseline value of 5.19 ng/ml to 2.45 ng/ml (p < 0.001) and MMP-9 decreased nonsignificantly from 360.50 ng/ml to 308.00 ng/ml. Corresponding values for the corn oil group were 0.54 mU/l to 0.59 mU/l for PAPP-A (p= 0.007), 5.27 ng/ml to 2.84 ng/ml for sCD-40 L (p< 0.001) and 430.00 ng/ml to 324.00 ng/ml for MMP-9 (p=ns), respectively. In conclusion; both interventions resulted in a significant rise in PAPP-A, a significant decrease in sCD40L and a non-significant decrease in MMP-9 after 12 months of treatment in MI survivors. No inter-group differences were noted." @default.
• W2099019831 created "2016-06-24" @default.
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• W2099019831 date "2006-01-01" @default.
• W2099019831 modified "2023-10-16" @default.
• W2099019831 title "Long term influence of regular intake of high dose n-3 fatty acids on CD40-ligand, pregnancy-associated plasma protein A and matrix metalloproteinase-9 following acute myocardial infarction" @default.
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• W2099019831 doi "https://doi.org/10.1160/th05-07-0497" @default.
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