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- W2099027225 abstract "<h3>Background:</h3> The importance of antinucleolar antibodies seen by indirect immunofluorescence on HEp-2 cells, although associated with systemic sclerosis (SSc), in unselected patients is unknown. <h3>Aims:</h3> To determine the true clinical significance of antinucleolar antibodies in an unselected patient population. <h3>Methods:</h3> Antinucleolar antibody (ANoA) positive samples were identified in the immunology laboratory during routine autoimmune screening tests; case notes were reviewed using a standard proforma. <h3>Results:</h3> 104 patients with ANoA were identified and ANoA<sup>+</sup> samples were subclassified into homogeneous, clumpy and speckled antinucleolar types. SSc was evident in only two (1.8%) patients. Other connective tissue diseases were identified in 33 patients (32%); 22 patients (21%) had evidence of various malignancies. Both disordered liver function and anaemia were seen in 22 patients and were the commonest laboratory abnormalities. <h3>Conclusions:</h3> Neither the presence nor subtype of ANoA is specific for systemic sclerosis. Laboratory comments appended to results should reflect this fact." @default.
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- W2099027225 date "2007-09-07" @default.
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- W2099027225 title "The clinical significance of antinucleolar antibodies" @default.
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- W2099027225 doi "https://doi.org/10.1136/jcp.2007.049692" @default.
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