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• W2099042745 abstract "Cellular systems are generally robust against fluctuations of intracellular parameters such as gene expression level. However, little is known about expression limits of genes required to halt cellular systems. In this study, using the fission yeast Schizosaccharomyces pombe, we developed a genetic 'tug-of-war' (gTOW) method to assess the overexpression limit of certain genes. Using gTOW, we determined copy number limits for 31 cell-cycle regulators; the limits varied from 1 to >100. Comparison with orthologs of the budding yeast Saccharomyces cerevisiae suggested the presence of a conserved fragile core in the eukaryotic cell cycle. Robustness profiles of networks regulating cytokinesis in both yeasts (septation-initiation network (SIN) and mitotic exit network (MEN)) were quite different, probably reflecting differences in their physiologic functions. Fragility in the regulation of GTPase spg1 was due to dosage imbalance against GTPase-activating protein (GAP) byr4. Using the gTOW data, we modified a mathematical model and successfully reproduced the robustness of the S. pombe cell cycle with the model." @default.
• W2099042745 created "2016-06-24" @default.
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• W2099042745 date "2011-01-01" @default.
• W2099042745 modified "2023-10-17" @default.
• W2099042745 title "Overexpression limits of fission yeast cell‐cycle regulators <i>in vivo</i> and <i>in silico</i>" @default.
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• W2099042745 doi "https://doi.org/10.1038/msb.2011.91" @default.
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