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- W2099046070 endingPage "641" @default.
- W2099046070 startingPage "626" @default.
- W2099046070 abstract "Coumarin derivatives, such as warfarin, acenocoumarol and phenprocoumon are frequently prescribed oral anticoagulants to treat and prevent thromboembolism. Because there is a large inter-individual and intra-individual variability in dose-response and a small therapeutic window, treatment with coumarin derivatives is challenging. Certain polymorphisms in CYP2C9 and VKORC1 are associated with lower dose requirements and a higher risk of bleeding. In this review we describe the use of different coumarin derivatives, pharmacokinetic characteristics of these drugs and differences amongst the coumarins. We also describe the current clinical challenges and the role of pharmacogenetic factors. These genetic factors are used to develop dosing algorithms and can be used to predict the right coumarin dose. The effectiveness of this new dosing strategy is currently being investigated in clinical trials." @default.
- W2099046070 created "2016-06-24" @default.
- W2099046070 creator A5009017786 @default.
- W2099046070 creator A5018590706 @default.
- W2099046070 creator A5038765957 @default.
- W2099046070 creator A5050903125 @default.
- W2099046070 creator A5076235099 @default.
- W2099046070 creator A5077437482 @default.
- W2099046070 date "2014-03-20" @default.
- W2099046070 modified "2023-10-15" @default.
- W2099046070 title "Pharmacogenetic-guided dosing of coumarin anticoagulants: algorithms for warfarin, acenocoumarol and phenprocoumon" @default.
- W2099046070 cites W1515782956 @default.
- W2099046070 cites W1528722311 @default.
- W2099046070 cites W1540761721 @default.
- W2099046070 cites W1558433062 @default.
- W2099046070 cites W1963891438 @default.
- W2099046070 cites W1967796257 @default.
- W2099046070 cites W1968825981 @default.
- W2099046070 cites W1972393846 @default.
- W2099046070 cites W1973774410 @default.
- W2099046070 cites W1976310686 @default.
- W2099046070 cites W1977030923 @default.
- W2099046070 cites W1977280638 @default.
- W2099046070 cites W1979608570 @default.
- W2099046070 cites W1979862336 @default.
- W2099046070 cites W1980564311 @default.
- W2099046070 cites W1982973803 @default.
- W2099046070 cites W1987938439 @default.
- W2099046070 cites W1990445874 @default.
- W2099046070 cites W1991888364 @default.
- W2099046070 cites W1992061685 @default.
- W2099046070 cites W1993614294 @default.
- W2099046070 cites W1997667641 @default.
- W2099046070 cites W1998269707 @default.
- W2099046070 cites W1999468381 @default.
- W2099046070 cites W2001523104 @default.
- W2099046070 cites W2002172465 @default.
- W2099046070 cites W2003475990 @default.
- W2099046070 cites W2004337162 @default.
- W2099046070 cites W2006914590 @default.
- W2099046070 cites W2009052297 @default.
- W2099046070 cites W2011403103 @default.
- W2099046070 cites W2012657970 @default.
- W2099046070 cites W2014783633 @default.
- W2099046070 cites W2014924181 @default.
- W2099046070 cites W2016935074 @default.
- W2099046070 cites W2017222282 @default.
- W2099046070 cites W2017538702 @default.
- W2099046070 cites W2018686854 @default.
- W2099046070 cites W2018787470 @default.
- W2099046070 cites W2018954315 @default.
- W2099046070 cites W2018997489 @default.
- W2099046070 cites W2022080080 @default.
- W2099046070 cites W2023487444 @default.
- W2099046070 cites W2024961352 @default.
- W2099046070 cites W2025144228 @default.
- W2099046070 cites W2025456062 @default.
- W2099046070 cites W2028350825 @default.
- W2099046070 cites W2028629982 @default.
- W2099046070 cites W2030112692 @default.
- W2099046070 cites W2032289591 @default.
- W2099046070 cites W2033085541 @default.
- W2099046070 cites W2037171637 @default.
- W2099046070 cites W2038118250 @default.
- W2099046070 cites W2039500477 @default.
- W2099046070 cites W2040808875 @default.
- W2099046070 cites W2042292509 @default.
- W2099046070 cites W2043660630 @default.
- W2099046070 cites W2047100625 @default.
- W2099046070 cites W2048802591 @default.
- W2099046070 cites W2050285407 @default.
- W2099046070 cites W2054039812 @default.
- W2099046070 cites W2054107817 @default.
- W2099046070 cites W2055250748 @default.
- W2099046070 cites W2055375232 @default.
- W2099046070 cites W2057250169 @default.
- W2099046070 cites W2059533196 @default.
- W2099046070 cites W2059587305 @default.
- W2099046070 cites W2061739968 @default.
- W2099046070 cites W2062272588 @default.
- W2099046070 cites W2062556628 @default.
- W2099046070 cites W2065976317 @default.
- W2099046070 cites W2066252978 @default.
- W2099046070 cites W2067670780 @default.
- W2099046070 cites W2068476516 @default.
- W2099046070 cites W2068634821 @default.
- W2099046070 cites W2072323519 @default.
- W2099046070 cites W2076349525 @default.
- W2099046070 cites W2078517865 @default.
- W2099046070 cites W2079247052 @default.
- W2099046070 cites W2079639349 @default.
- W2099046070 cites W2084929494 @default.
- W2099046070 cites W2085067513 @default.
- W2099046070 cites W2086465057 @default.
- W2099046070 cites W2087646765 @default.
- W2099046070 cites W2090225839 @default.
- W2099046070 cites W2093658225 @default.
- W2099046070 cites W2096126922 @default.