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- W2099053491 abstract "The murine molecule dectin-1 (known as the β-glucan receptor in humans) is an immune cell surface receptor implicated in the immunological defense against fungal pathogens. Sequence analysis has indicated that the dectin-1 extracellular domain is a C-type lectin-like domain, and functional studies have established that it binds fungal β-glucans. We report several dectin-1 crystal structures, including a high-resolution structure and a 2.8 Å resolution structure in which a short soaked natural β-glucan is trapped in the crystal lattice. In vitro characterization of dectin-1 in the presence of its natural ligand indicates higher-order complex formation between dectin-1 and β-glucans. These combined structural and biophysical data considerably extend the current knowledge of dectin-1 structure and function, and suggest potential mechanisms of defense against fungal pathogens." @default.
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- W2099053491 date "2007-06-01" @default.
- W2099053491 modified "2023-10-18" @default.
- W2099053491 title "Structure of the fungal β-glucan-binding immune receptor dectin-1: Implications for function" @default.
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- W2099053491 doi "https://doi.org/10.1110/ps.072791207" @default.
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