FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099079553> ?p ?o ?g. }

• W2099079553 endingPage "37" @default.
• W2099079553 startingPage "8629" @default.
• W2099079553 abstract "Vascular endothelial growth factor (VEGF) is a dimeric angiogenic factor that is overexpressed by many tumors and stimulates tumor angiogenesis. VEGF initiates signaling by dimerizing the receptors VEGFR-1 and VEGFR-2. The Fas receptor stimulates apoptosis, and artificial dimerization of the Fas cytoplasmic domain has been shown to induce apoptosis. We constructed a chimeric receptor (VEGFR2Fas) combining the extracellular and transmembrane domains of VEGFR-2 with the cytoplasmic domain of Fas receptor. When VEGFR2Fas was stably expressed in endothelial cells in vitro, treatment with VEGF rapidly induced cell death with features characteristic of Fas-mediated apoptosis. These findings demonstrate that VEGFR2Fas functions as a VEGF-triggered death receptor and raise the possibility that introduction of VEGFR2Fas into tumor endothelium or tumor cells in vivo may convert tumor-derived VEGF from an angiogenic factor into an antiangiogenesis agent." @default.
• W2099079553 created "2016-06-24" @default.
• W2099079553 creator A5003828486 @default.
• W2099079553 creator A5025998503 @default.
• W2099079553 creator A5036090510 @default.
• W2099079553 creator A5040323150 @default.
• W2099079553 creator A5062291958 @default.
• W2099079553 date "2001-12-15" @default.
• W2099079553 modified "2023-09-23" @default.
• W2099079553 title "A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis." @default.
• W2099079553 cites W1558647085 @default.
• W2099079553 cites W1560710410 @default.
• W2099079553 cites W1593130318 @default.
• W2099079553 cites W1627004187 @default.
• W2099079553 cites W1671345421 @default.
• W2099079553 cites W1963134446 @default.
• W2099079553 cites W1969328947 @default.
• W2099079553 cites W1970770376 @default.
• W2099079553 cites W1972671115 @default.
• W2099079553 cites W1976552319 @default.
• W2099079553 cites W1981612052 @default.
• W2099079553 cites W1983622721 @default.
• W2099079553 cites W1989891990 @default.
• W2099079553 cites W2005189888 @default.
• W2099079553 cites W2013141629 @default.
• W2099079553 cites W2023453327 @default.
• W2099079553 cites W2026038921 @default.
• W2099079553 cites W2027573743 @default.
• W2099079553 cites W2027669852 @default.
• W2099079553 cites W2034646933 @default.
• W2099079553 cites W2064982197 @default.
• W2099079553 cites W2067817921 @default.
• W2099079553 cites W2069043370 @default.
• W2099079553 cites W2084506573 @default.
• W2099079553 cites W2110844953 @default.
• W2099079553 cites W2133726754 @default.
• W2099079553 cites W2150048971 @default.
• W2099079553 cites W2166156136 @default.
• W2099079553 cites W2341149903 @default.
• W2099079553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11751375" @default.
• W2099079553 hasPublicationYear "2001" @default.
• W2099079553 type Work @default.
• W2099079553 sameAs 2099079553 @default.
• W2099079553 citedByCount "4" @default.
• W2099079553 countsByYear W20990795532022 @default.
• W2099079553 crossrefType "journal-article" @default.
• W2099079553 hasAuthorship W2099079553A5003828486 @default.
• W2099079553 hasAuthorship W2099079553A5025998503 @default.
• W2099079553 hasAuthorship W2099079553A5036090510 @default.
• W2099079553 hasAuthorship W2099079553A5040323150 @default.
• W2099079553 hasAuthorship W2099079553A5062291958 @default.
• W2099079553 hasConcept C103041312 @default.
• W2099079553 hasConcept C123012128 @default.
• W2099079553 hasConcept C146285616 @default.
• W2099079553 hasConcept C14858245 @default.
• W2099079553 hasConcept C150710994 @default.
• W2099079553 hasConcept C15215337 @default.
• W2099079553 hasConcept C167734588 @default.
• W2099079553 hasConcept C170493617 @default.
• W2099079553 hasConcept C185592680 @default.
• W2099079553 hasConcept C190283241 @default.
• W2099079553 hasConcept C202751555 @default.
• W2099079553 hasConcept C2777025900 @default.
• W2099079553 hasConcept C2780394083 @default.
• W2099079553 hasConcept C31573885 @default.
• W2099079553 hasConcept C502942594 @default.
• W2099079553 hasConcept C55493867 @default.
• W2099079553 hasConcept C66008609 @default.
• W2099079553 hasConcept C86803240 @default.
• W2099079553 hasConcept C95444343 @default.
• W2099079553 hasConceptScore W2099079553C103041312 @default.
• W2099079553 hasConceptScore W2099079553C123012128 @default.
• W2099079553 hasConceptScore W2099079553C146285616 @default.
• W2099079553 hasConceptScore W2099079553C14858245 @default.
• W2099079553 hasConceptScore W2099079553C150710994 @default.
• W2099079553 hasConceptScore W2099079553C15215337 @default.
• W2099079553 hasConceptScore W2099079553C167734588 @default.
• W2099079553 hasConceptScore W2099079553C170493617 @default.
• W2099079553 hasConceptScore W2099079553C185592680 @default.
• W2099079553 hasConceptScore W2099079553C190283241 @default.
• W2099079553 hasConceptScore W2099079553C202751555 @default.
• W2099079553 hasConceptScore W2099079553C2777025900 @default.
• W2099079553 hasConceptScore W2099079553C2780394083 @default.
• W2099079553 hasConceptScore W2099079553C31573885 @default.
• W2099079553 hasConceptScore W2099079553C502942594 @default.
• W2099079553 hasConceptScore W2099079553C55493867 @default.
• W2099079553 hasConceptScore W2099079553C66008609 @default.
• W2099079553 hasConceptScore W2099079553C86803240 @default.
• W2099079553 hasConceptScore W2099079553C95444343 @default.
• W2099079553 hasIssue "24" @default.
• W2099079553 hasLocation W20990795531 @default.
• W2099079553 hasOpenAccess W2099079553 @default.
• W2099079553 hasPrimaryLocation W20990795531 @default.
• W2099079553 hasRelatedWork W1982972760 @default.
• W2099079553 hasRelatedWork W1999133609 @default.
• W2099079553 hasRelatedWork W1999296939 @default.
• W2099079553 hasRelatedWork W2062627489 @default.
• W2099079553 hasRelatedWork W2090763994 @default.

• next