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• W2099080246 abstract "Genome-scan methods are used for screening genomewide patterns of DNA polymorphism to detect signatures of positive selection. There are two main types of methods: (i) ‘outlier’ detection methods based on that detect loci with high differentiation compared to the rest of the genome and (ii) environmental association methods that test the association between allele frequencies and environmental variables. We present a new -based genome-scan method, BayeScEnv, which incorporates environmental information in the form of ‘environmental differentiation’. It is based on the F model, but, as opposed to existing approaches, it considers two locus-specific effects: one due to divergent selection and the other due to various other processes different from local adaptation (e.g. range expansions, differences in mutation rates across loci or background selection). The method was developped in C++ and is available at http://github.com/devillemereuil/bayescenv. A simulation study shows that our method has a much lower false positive rate than an existing -based method, BayeScan, under a wide range of demographic scenarios. Although it has lower power, it leads to a better compromise between power and false positive rate. We apply our method to a human data set and show that it can be used successfully to study local adaptation. We discuss its scope and compare it to other existing methods." @default.
• W2099080246 created "2016-06-24" @default.
• W2099080246 creator A5005209578 @default.
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• W2099080246 date "2015-07-19" @default.
• W2099080246 modified "2023-10-12" @default.
• W2099080246 title "A new F_ST‐based method to uncover local adaptation using environmental variables" @default.
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• W2099080246 doi "https://doi.org/10.1111/2041-210x.12418" @default.
• W2099080246 hasPublicationYear "2015" @default.
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