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• W2099083365 abstract "Recurrent pregnancy loss (RPL), which occurs in 0.5%–1% of total pregnancies, is usually defined as three or more consecutive spontaneous abortions before 20 weeks of gestation. Although an immunology-based etiology underlying unexplained RPL has been demonstrated, the exact molecular mechanisms are still poorly understood. Recent studies using transcriptomics and proteomics have implicated several factors. Here, we review the key possible mechanisms, in particular immunological abnormalities and thrombophilic aberration, that might underlie RPL. Taken together, these findings provide insight into the development of effective therapeutics for RPL. Recurrent pregnancy loss (RPL), which occurs in 0.5%–1% of total pregnancies, is usually defined as three or more consecutive spontaneous abortions before 20 weeks of gestation. Although an immunology-based etiology underlying unexplained RPL has been demonstrated, the exact molecular mechanisms are still poorly understood. Recent studies using transcriptomics and proteomics have implicated several factors. Here, we review the key possible mechanisms, in particular immunological abnormalities and thrombophilic aberration, that might underlie RPL. Taken together, these findings provide insight into the development of effective therapeutics for RPL. fluid produced by the secretion by granulose cells and by diffusion from the theca capillaries during folliculogenesis. It contains essential substances involved in follicle growth and oocyte fertilization in the mammalian reproductive process. the study of genes and their function. It includes, for example, functional genomics, structural genomics, comparative genomics, epigenomics and pharmacogenomics. a cluster of genes that are located on a chromosome concerned with antigen production and are critical for the success of transplantation. the development of hypertension with proteinuria or edema, or both, due to pregnancy or the influence of a recent pregnancy. the study of the proteome, the complete set of proteins produced by an organelle, cell, tissue or entire organism, via the technologies of large-scale protein separation and identification. three or more clinical pregnancy losses before the 20th week of gestation. the formation or presence of blood clotting in a blood vessel. the study of the transcriptome, the complete set of RNA transcripts produced by the genome at any one time." @default.
• W2099083365 created "2016-06-24" @default.
• W2099083365 creator A5007366966 @default.
• W2099083365 creator A5052100533 @default.
• W2099083365 creator A5083993092 @default.
• W2099083365 date "2007-07-01" @default.
• W2099083365 modified "2023-10-11" @default.
• W2099083365 title "Recurrent pregnancy loss: the key potential mechanisms" @default.
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• W2099083365 doi "https://doi.org/10.1016/j.molmed.2007.05.005" @default.
• W2099083365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17574920" @default.
• W2099083365 hasPublicationYear "2007" @default.
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