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- W2099108776 abstract "Nitric oxide (NO) and the many derivatives and reactive oxygen intermediates thereof are all molecules that are utilised by mammalian cells in the war against microbial pathogens and tumours. They are potentially toxic molecules and, with damage control being crucial, the production and metabolism of nitric oxide is a tightly regulated process. The duality of NO is well documented. On the one hand, beneficial effects include normal healing in the skin and intestinal mucosa, killing of certain bacteria, regulating T cell proliferation and differentiation (Th1 vs Th2), and regulating leukocyte recruitment, by affecting adhesion molecule expression. On the other hand, persistent high levels of NO can lead to the production of toxic metabolites (peroxynitrite and hydroxyls), which can have detrimental effects, such as increased microvascular and epithelial permeability, increased oxidative stress (which can damage DNA), and damage to iron-sulphur proteins in mitochondria. NO has been reported to modulate its own production and the mechanisms involved in this self-regulation are being hotly pursued. The purpose of this review is to update recent intriguing advances in our understanding of the interaction of the phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathway in regulating the activity of the enzymes that generate NO, namely, the nitric oxide synthases." @default.
- W2099108776 created "2016-06-24" @default.
- W2099108776 creator A5029868837 @default.
- W2099108776 creator A5036999979 @default.
- W2099108776 date "2000-09-01" @default.
- W2099108776 modified "2023-09-24" @default.
- W2099108776 title "Interactions between Phosphatidylinositol 3-Kinase and Nitric Oxide: Explaining the Paradox" @default.
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- W2099108776 doi "https://doi.org/10.1006/mcbr.2001.0273" @default.
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