FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099126598> ?p ?o ?g. }

• W2099126598 endingPage "232" @default.
• W2099126598 startingPage "211" @default.
• W2099126598 abstract "SUMMARY The viral infectivity factor (Vif) is dispensable for human immunodeficiency virus type 1 (HIV-1) replication in so-called permissive cells but is required for replication in nonpermissive cell lines and for pathogenesis. Virions produced in the absence of Vif have an aberrant morphology and an unstable core and are unable to complete reverse transcription. Recent studies demonstrated that human APOBEC-3G (hA3G) and APOBEC-3F (hA3F), which are selectively expressed in nonpermissive cells, possess strong anti-HIV-1 activity and are sufficient to confer a nonpermissive phenotype. Vif induces the degradation of hA3G and hA3F, suggesting that its main function is to counteract these cellular factors. Most studies focused on the hypermutation induced by the cytidine deaminase activity of hA3G and hA3F and on their Vif-induced degradation by the proteasome. However, recent studies suggested that several mechanisms are involved both in the antiviral activity of hA3G and hA3F and in the way Vif counteracts these antiviral factors. Attempts to reconcile the studies involving Vif in virus assembly and stability with these recent findings suggest that hA3G and hA3F partially exert their antiviral activity independently of their catalytic activity by destabilizing the viral core and the reverse transcription complex, possibly by interfering with the assembly and/or maturation of the viral particles. Vif could then counteract hA3G and hA3F by excluding them from the viral assembly intermediates through competition for the viral genomic RNA, by regulating the proteolytic processing of Pr55 Gag , by enhancing the efficiency of the reverse transcription process, and by inhibiting the enzymatic activities of hA3G and hA3F." @default.
• W2099126598 created "2016-06-24" @default.
• W2099126598 creator A5043443505 @default.
• W2099126598 creator A5067427655 @default.
• W2099126598 creator A5067744333 @default.
• W2099126598 creator A5074853734 @default.
• W2099126598 creator A5079724200 @default.
• W2099126598 date "2009-06-01" @default.
• W2099126598 modified "2023-09-27" @default.
• W2099126598 title "Tumultuous Relationship between the Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) and the Human APOBEC-3G and APOBEC-3F Restriction Factors" @default.
• W2099126598 cites W119758260 @default.
• W2099126598 cites W1480555318 @default.
• W2099126598 cites W1490329041 @default.
• W2099126598 cites W1501423712 @default.
• W2099126598 cites W1507156025 @default.
• W2099126598 cites W1507598539 @default.
• W2099126598 cites W1515041121 @default.
• W2099126598 cites W1518031686 @default.
• W2099126598 cites W1540217756 @default.
• W2099126598 cites W1546971287 @default.
• W2099126598 cites W1550872944 @default.
• W2099126598 cites W1551456716 @default.
• W2099126598 cites W1557952727 @default.
• W2099126598 cites W1573886646 @default.
• W2099126598 cites W1585397042 @default.
• W2099126598 cites W1595806441 @default.
• W2099126598 cites W1623326129 @default.
• W2099126598 cites W1664638011 @default.
• W2099126598 cites W1669297435 @default.
• W2099126598 cites W1744129015 @default.
• W2099126598 cites W1796915314 @default.
• W2099126598 cites W1823163918 @default.
• W2099126598 cites W1851544526 @default.
• W2099126598 cites W1856653403 @default.
• W2099126598 cites W1896943425 @default.
• W2099126598 cites W1908681406 @default.
• W2099126598 cites W1919273552 @default.
• W2099126598 cites W1936863780 @default.
• W2099126598 cites W1947454506 @default.
• W2099126598 cites W1953633494 @default.
• W2099126598 cites W1963594716 @default.
• W2099126598 cites W1964493335 @default.
• W2099126598 cites W1964682086 @default.
• W2099126598 cites W1966343819 @default.
• W2099126598 cites W1967406495 @default.
• W2099126598 cites W1967513429 @default.
• W2099126598 cites W1967614573 @default.
• W2099126598 cites W1968292498 @default.
• W2099126598 cites W1970120490 @default.
• W2099126598 cites W1970288540 @default.
• W2099126598 cites W1971644910 @default.
• W2099126598 cites W1972739934 @default.
• W2099126598 cites W1972865566 @default.
• W2099126598 cites W1973598278 @default.
• W2099126598 cites W1976819921 @default.
• W2099126598 cites W1978920270 @default.
• W2099126598 cites W1984910512 @default.
• W2099126598 cites W1985716301 @default.
• W2099126598 cites W1986123487 @default.
• W2099126598 cites W1986198261 @default.
• W2099126598 cites W1986894155 @default.
• W2099126598 cites W1988383488 @default.
• W2099126598 cites W1990080035 @default.
• W2099126598 cites W1990248095 @default.
• W2099126598 cites W1990668026 @default.
• W2099126598 cites W1990700813 @default.
• W2099126598 cites W1990993204 @default.
• W2099126598 cites W1991069890 @default.
• W2099126598 cites W1992127199 @default.
• W2099126598 cites W1992325700 @default.
• W2099126598 cites W1992872270 @default.
• W2099126598 cites W1992984336 @default.
• W2099126598 cites W1993095717 @default.
• W2099126598 cites W1993897877 @default.
• W2099126598 cites W1994195473 @default.
• W2099126598 cites W1994599395 @default.
• W2099126598 cites W1995117749 @default.
• W2099126598 cites W1996145257 @default.
• W2099126598 cites W1997746246 @default.
• W2099126598 cites W2000620255 @default.
• W2099126598 cites W2001070158 @default.
• W2099126598 cites W2001199134 @default.
• W2099126598 cites W2001375348 @default.
• W2099126598 cites W2002101536 @default.
• W2099126598 cites W2003811687 @default.
• W2099126598 cites W2004640739 @default.
• W2099126598 cites W2005044802 @default.
• W2099126598 cites W2006699168 @default.
• W2099126598 cites W2007856011 @default.
• W2099126598 cites W2007978409 @default.
• W2099126598 cites W2009378735 @default.
• W2099126598 cites W2009808421 @default.
• W2099126598 cites W2009846118 @default.
• W2099126598 cites W2011743752 @default.
• W2099126598 cites W2012564250 @default.
• W2099126598 cites W2012816540 @default.
• W2099126598 cites W2014067586 @default.
• W2099126598 cites W2014104147 @default.

• next