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- W2099166543 abstract "Synaptic plasticity, which is the neuronal substrate for many forms of hippocampus-dependent learning, is attenuated by GABA type A receptor (GABA A R)-mediated inhibition. The prevailing notion is that a synaptic or phasic form of GABAergic inhibition regulates synaptic plasticity; however, little is known about the role of GABA A R subtypes that generate a tonic or persistent inhibitory conductance. We studied the regulation of synaptic plasticity by α5 subunit-containing GABA A Rs (α5GABA A Rs), which generate a tonic inhibitory conductance in CA1 pyramidal neurons using electrophysiological recordings of field and whole-cell potentials in hippocampal slices from both wild-type and null mutant mice for the α5 subunit of the GABA A R ( Gabra5 −/− mice). In addition, the strength of fear-associated memory was studied. The results showed that α5GABA A R activity raises the threshold for induction of long-term potentiation in a highly specific band of stimulation frequencies (10–20 Hz) through mechanisms that are predominantly independent of inhibitory synaptic transmission. The deletion or pharmacological inhibition of α5GABA A Rs caused no change in baseline membrane potential or input resistance but increased depolarization during 10 Hz stimulation. The encoding of hippocampus-dependent memory was regulated by α5GABA A Rs but only under specific conditions that generate moderate but not robust forms of fear-associated learning. Thus, under specific conditions, α5GABA A R activity predominates over synaptic inhibition in modifying the strength of both synaptic plasticity in vitro and certain forms of memory in vivo ." @default.
- W2099166543 created "2016-06-24" @default.
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- W2099166543 creator A5049734978 @default.
- W2099166543 creator A5056543120 @default.
- W2099166543 creator A5078772136 @default.
- W2099166543 date "2010-04-14" @default.
- W2099166543 modified "2023-09-30" @default.
- W2099166543 title "α5GABA<sub>A</sub>Receptor Activity Sets the Threshold for Long-Term Potentiation and Constrains Hippocampus-Dependent Memory" @default.
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- W2099166543 doi "https://doi.org/10.1523/jneurosci.4209-09.2010" @default.
- W2099166543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6632746" @default.
- W2099166543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20392949" @default.