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- W2099166599 abstract "Introduction: Breast cancer is the most common form of malignancy occurring in women worldwide. B7-H1 is a co-inhibitory molecule expressed by several types of tumors, including breast cancer. The aberrant expression of B7-H1 in breast cancer cells has been determined, its role in recruiting regulatory T cells into the tumor microenvironment has been elucidated and a strong link to B7-H1 induction in highly proliferative breast cancer has been provided. It has also been demonstrated that doxorubicin, a drug commonly used for breast cancer treatment, downregulates the cell surface expression of B7-H1 and upregulates its nuclear expression, which therefore suggests an anti-apoptotic role of B7-H1 in breast cancer. Areas covered: This review illustrates the various factors involved in the induction of B7-H1 and its role in immune evasion and chemoresistance. It also provides potential therapeutic strategies for targeting B7-H1 in breast cancer. Expert opinion: B7-H1 should be considered as a potential therapeutic target for breast cancer. Indeed, there is increasing evidence for the potential efficacy of B7-H1 blockade in the prevention of immune evasion by cancer cells. Additionally, B7-H1 targeting can be used in conjunction with other therapeutic modalities for improved efficacy and reduced toxicity. We expect that B7-H1 blockade in combination with other therapeutics will be a prime therapeutic strategy in the future." @default.
- W2099166599 created "2016-06-24" @default.
- W2099166599 creator A5012513454 @default.
- W2099166599 creator A5025251801 @default.
- W2099166599 creator A5043593241 @default.
- W2099166599 creator A5085371836 @default.
- W2099166599 creator A5087828930 @default.
- W2099166599 date "2011-08-28" @default.
- W2099166599 modified "2023-09-29" @default.
- W2099166599 title "Therapeutic targeting of B7-H1 in breast cancer" @default.
- W2099166599 cites W1498169316 @default.
- W2099166599 cites W1513840351 @default.
- W2099166599 cites W1566738222 @default.
- W2099166599 cites W1568317937 @default.
- W2099166599 cites W1935842090 @default.
- W2099166599 cites W1961026612 @default.
- W2099166599 cites W1966577330 @default.
- W2099166599 cites W1971641493 @default.
- W2099166599 cites W1985126564 @default.
- W2099166599 cites W1990779902 @default.
- W2099166599 cites W1994238092 @default.
- W2099166599 cites W2000609012 @default.
- W2099166599 cites W2002235017 @default.
- W2099166599 cites W2002726823 @default.
- W2099166599 cites W2010121426 @default.
- W2099166599 cites W2010183849 @default.
- W2099166599 cites W2010871781 @default.
- W2099166599 cites W2011612270 @default.
- W2099166599 cites W2011960130 @default.
- W2099166599 cites W2013090484 @default.
- W2099166599 cites W2016612145 @default.
- W2099166599 cites W2016732129 @default.
- W2099166599 cites W2019665138 @default.
- W2099166599 cites W2022179692 @default.
- W2099166599 cites W2022580424 @default.
- W2099166599 cites W2029946790 @default.
- W2099166599 cites W2031770999 @default.
- W2099166599 cites W2032818767 @default.
- W2099166599 cites W2033576171 @default.
- W2099166599 cites W2037634641 @default.
- W2099166599 cites W2038154111 @default.
- W2099166599 cites W2038284978 @default.
- W2099166599 cites W2039427849 @default.
- W2099166599 cites W2041560123 @default.
- W2099166599 cites W2042729766 @default.
- W2099166599 cites W2044224425 @default.
- W2099166599 cites W2050302729 @default.
- W2099166599 cites W2050999762 @default.
- W2099166599 cites W2061429827 @default.
- W2099166599 cites W2061913910 @default.
- W2099166599 cites W2063264144 @default.
- W2099166599 cites W2064052354 @default.
- W2099166599 cites W2065409049 @default.
- W2099166599 cites W2066555244 @default.
- W2099166599 cites W2069274376 @default.
- W2099166599 cites W2070580147 @default.
- W2099166599 cites W2072448714 @default.
- W2099166599 cites W2076457965 @default.
- W2099166599 cites W2077597327 @default.
- W2099166599 cites W2080036187 @default.
- W2099166599 cites W2080612883 @default.
- W2099166599 cites W2081447339 @default.
- W2099166599 cites W2085257327 @default.
- W2099166599 cites W2086437355 @default.
- W2099166599 cites W2093334570 @default.
- W2099166599 cites W2093424661 @default.
- W2099166599 cites W2094155438 @default.
- W2099166599 cites W2097855813 @default.
- W2099166599 cites W2099175643 @default.
- W2099166599 cites W2099491780 @default.
- W2099166599 cites W2100001853 @default.
- W2099166599 cites W2104322194 @default.
- W2099166599 cites W2104732141 @default.
- W2099166599 cites W2106926141 @default.
- W2099166599 cites W2108604103 @default.
- W2099166599 cites W2108855090 @default.
- W2099166599 cites W2111217091 @default.
- W2099166599 cites W2112595184 @default.
- W2099166599 cites W2113399114 @default.
- W2099166599 cites W2118471749 @default.
- W2099166599 cites W2121988130 @default.
- W2099166599 cites W2122184221 @default.
- W2099166599 cites W2125068253 @default.
- W2099166599 cites W2128540669 @default.
- W2099166599 cites W2130207101 @default.
- W2099166599 cites W2130272079 @default.
- W2099166599 cites W2131577873 @default.
- W2099166599 cites W2134345729 @default.
- W2099166599 cites W2136313650 @default.
- W2099166599 cites W2138590389 @default.
- W2099166599 cites W2140633375 @default.
- W2099166599 cites W2142153200 @default.
- W2099166599 cites W2142414417 @default.
- W2099166599 cites W2150372796 @default.
- W2099166599 cites W2150678612 @default.
- W2099166599 cites W2160117150 @default.
- W2099166599 cites W2161558877 @default.
- W2099166599 cites W2162462666 @default.