FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099170614> ?p ?o ?g. }

• W2099170614 endingPage "723" @default.
• W2099170614 startingPage "712" @default.
• W2099170614 abstract "The COP1/SPA complex acts as an E3 ubiquitin ligase to repress photomorphogenesis by targeting activators of the light response for degradation. Genetic analysis has shown that the four members of the SPA gene family (SPA1-SPA4) have overlapping but distinct functions. In particular, SPA1 and SPA2 differ in that SPA1 encodes a potent repressor in light- and dark-grown seedlings, but SPA2 fully loses its function when seedlings are exposed to light, indicating that SPA2 function is hyper-inactivated by light. Here, we have used chimeric SPA1/SPA2 constructs to show that the distinct functions of SPA1 and SPA2 genes in light-grown seedlings are due to the SPA protein sequences and independent of the SPA promoter sequences. Biochemical analysis of SPA1 and SPA2 protein levels shows that light exposure leads to rapid proteasomal degradation of SPA2, and, more weakly, of SPA1, but not of COP1. This suggests that light inactivates the COP1/SPA complex partly by reducing SPA protein levels. Although SPA2 was more strongly degraded than SPA1, this was not the sole reason for the lack of SPA2 function in the light. We found that the SPA2 protein is inherently incapable of repressing photomorphogenesis in light-grown seedlings. The data therefore indicate that light inactivates the function of SPA2 through a post-translational mechanism that eliminates the activity of the remaining SPA2 protein in the cell." @default.
• W2099170614 created "2016-06-24" @default.
• W2099170614 creator A5023010103 @default.
• W2099170614 creator A5043196249 @default.
• W2099170614 creator A5057290282 @default.
• W2099170614 creator A5064886500 @default.
• W2099170614 creator A5066193183 @default.
• W2099170614 creator A5072456576 @default.
• W2099170614 creator A5072523350 @default.
• W2099170614 creator A5073206096 @default.
• W2099170614 date "2011-01-14" @default.
• W2099170614 modified "2023-10-16" @default.
• W2099170614 title "Light exposure of Arabidopsis seedlings causes rapid de-stabilization as well as selective post-translational inactivation of the repressor of photomorphogenesis SPA2" @default.
• W2099170614 cites W1516409823 @default.
• W2099170614 cites W1781598802 @default.
• W2099170614 cites W1968382037 @default.
• W2099170614 cites W1984934120 @default.
• W2099170614 cites W1989001617 @default.
• W2099170614 cites W1992258446 @default.
• W2099170614 cites W1998053175 @default.
• W2099170614 cites W2006153112 @default.
• W2099170614 cites W2019364309 @default.
• W2099170614 cites W2050004861 @default.
• W2099170614 cites W2054857943 @default.
• W2099170614 cites W2065124055 @default.
• W2099170614 cites W2076950362 @default.
• W2099170614 cites W2091407616 @default.
• W2099170614 cites W2100464344 @default.
• W2099170614 cites W2111586761 @default.
• W2099170614 cites W2112826362 @default.
• W2099170614 cites W2121325508 @default.
• W2099170614 cites W2132650496 @default.
• W2099170614 cites W2133307159 @default.
• W2099170614 cites W2137501007 @default.
• W2099170614 cites W2138621166 @default.
• W2099170614 cites W2140019714 @default.
• W2099170614 cites W2151723682 @default.
• W2099170614 cites W2161064670 @default.
• W2099170614 cites W2166394224 @default.
• W2099170614 cites W2167239493 @default.
• W2099170614 cites W2169121089 @default.
• W2099170614 cites W4238274553 @default.
• W2099170614 doi "https://doi.org/10.1111/j.1365-313x.2010.04456.x" @default.
• W2099170614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21235648" @default.
• W2099170614 hasPublicationYear "2011" @default.
• W2099170614 type Work @default.
• W2099170614 sameAs 2099170614 @default.
• W2099170614 citedByCount "53" @default.
• W2099170614 countsByYear W20991706142012 @default.
• W2099170614 countsByYear W20991706142013 @default.
• W2099170614 countsByYear W20991706142014 @default.
• W2099170614 countsByYear W20991706142015 @default.
• W2099170614 countsByYear W20991706142016 @default.
• W2099170614 countsByYear W20991706142017 @default.
• W2099170614 countsByYear W20991706142018 @default.
• W2099170614 countsByYear W20991706142019 @default.
• W2099170614 countsByYear W20991706142020 @default.
• W2099170614 countsByYear W20991706142021 @default.
• W2099170614 countsByYear W20991706142022 @default.
• W2099170614 countsByYear W20991706142023 @default.
• W2099170614 crossrefType "journal-article" @default.
• W2099170614 hasAuthorship W2099170614A5023010103 @default.
• W2099170614 hasAuthorship W2099170614A5043196249 @default.
• W2099170614 hasAuthorship W2099170614A5057290282 @default.
• W2099170614 hasAuthorship W2099170614A5064886500 @default.
• W2099170614 hasAuthorship W2099170614A5066193183 @default.
• W2099170614 hasAuthorship W2099170614A5072456576 @default.
• W2099170614 hasAuthorship W2099170614A5072523350 @default.
• W2099170614 hasAuthorship W2099170614A5073206096 @default.
• W2099170614 hasBestOaLocation W20991706141 @default.
• W2099170614 hasConcept C104317684 @default.
• W2099170614 hasConcept C134459356 @default.
• W2099170614 hasConcept C143065580 @default.
• W2099170614 hasConcept C150194340 @default.
• W2099170614 hasConcept C158448853 @default.
• W2099170614 hasConcept C25602115 @default.
• W2099170614 hasConcept C2779491563 @default.
• W2099170614 hasConcept C2779922708 @default.
• W2099170614 hasConcept C2781446133 @default.
• W2099170614 hasConcept C54355233 @default.
• W2099170614 hasConcept C5911399 @default.
• W2099170614 hasConcept C86803240 @default.
• W2099170614 hasConcept C95444343 @default.
• W2099170614 hasConceptScore W2099170614C104317684 @default.
• W2099170614 hasConceptScore W2099170614C134459356 @default.
• W2099170614 hasConceptScore W2099170614C143065580 @default.
• W2099170614 hasConceptScore W2099170614C150194340 @default.
• W2099170614 hasConceptScore W2099170614C158448853 @default.
• W2099170614 hasConceptScore W2099170614C25602115 @default.
• W2099170614 hasConceptScore W2099170614C2779491563 @default.
• W2099170614 hasConceptScore W2099170614C2779922708 @default.
• W2099170614 hasConceptScore W2099170614C2781446133 @default.
• W2099170614 hasConceptScore W2099170614C54355233 @default.
• W2099170614 hasConceptScore W2099170614C5911399 @default.
• W2099170614 hasConceptScore W2099170614C86803240 @default.
• W2099170614 hasConceptScore W2099170614C95444343 @default.
• W2099170614 hasIssue "5" @default.
• W2099170614 hasLocation W20991706141 @default.

• next