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- W2099186633 abstract "The phenomenon of cardiac memory refers to persistent response of the heart to an external pacing stimulus, where the response typically outlasts the stimulus. It is a fundamental tenet of neuroscience that synaptic modification is the basis of various forms of learning and memory. Drawing analogy with neural synapses and Gap Junctions (GJs) in the cardiac tissue, we had earlier hypothesized that dynamic, voltage-sensitive change in GJ conductance may be related to the phenomenon of cardiac memory. In this work we have coupled cardiac cells by GJ conductance. The GJ conductance is allowed to vary as a function of junctional voltage. Simulations show the cell pair and GJ system has two stable states: one at a high value of GJ conductance and another at a lower value. The system can be switched between the two states by an appropriate external input. Such bistable dynamics can support memory operations and most probably underlie the phenomenon of cardiac memory. There are three kinds of cell pairs are considered: (1) a Noble-Noble cell pair that represents adjacent cells in Purkinje network, (2) a pair of DiFranceso-Noble cells that represents adjacent SA nodal cells, and (3) a model of Noble cell coupled to Luo-Rudy cell model, which represents an interacting pair of a Purkinje fiber and a ventricular myocyte. Bistability is demonstrated in all the three cases and this bistability might be an underlying factor behind cardiac memory. Focused analysis of a pair of Noble cell models showed that bistability is obtained only when the properties of GJs “match” with the properties of the pair of cells that is coupled by the GJs. This study showed the role of GJ channels in cardiac memory." @default.
- W2099186633 created "2016-06-24" @default.
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- W2099186633 date "2011-02-01" @default.
- W2099186633 modified "2023-09-30" @default.
- W2099186633 title "Role of Gap Junction Channels on Cardiac Memory" @default.
- W2099186633 doi "https://doi.org/10.1016/j.bpj.2010.12.2583" @default.
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