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• W2099187360 abstract "As the genetics of neurodegenerative disease become better understood, opportunities for genetic susceptibility testing for at-risk individuals will increase. Such testing raises important ethical and practice issues related to test access, informed consent, risk estimation and communication, return of results, and policies to prevent genetic discrimination. The advent of direct-to-consumer genetic susceptibility testing for various neurodegenerative disorders (including Alzheimer's disease (AD), Parkinson's disease, and certain prion diseases) means that ethical and practical challenges must be faced not only in traditional research and clinical settings, but also in broader society. This review addresses several topics relevant to the development and implementation of genetic susceptibility tests across research, clinical, and consumer settings; these include appropriate indications for testing, the implications of different methods for disclosing test results, clinical versus personal utility of risk information, psychological and behavioral responses to test results, testing of minors, genetic discrimination, and ethical dilemmas posed by whole-genome sequencing. We also identify future areas of likely growth in the field, including pharmacogenomics and genetic screening for individuals considering or engaged in activities that pose elevated risk of brain injury (e.g., football players, military personnel). APOE gene testing for risk of Alzheimer's disease is used throughout as an instructive case example, drawing upon the authors’ experience as investigators in a series of multisite randomized clinical trials that have examined the impact of disclosing APOE genotype status to interested individuals (e.g., first-degree relatives of AD patients, persons with mild cognitive impairment)." @default.
• W2099187360 created "2016-06-24" @default.
• W2099187360 creator A5006035931 @default.
• W2099187360 creator A5032814424 @default.
• W2099187360 date "2013-11-01" @default.
• W2099187360 modified "2023-10-15" @default.
• W2099187360 title "Genetic susceptibility testing for neurodegenerative diseases: Ethical and practice issues" @default.
• W2099187360 cites W116454012 @default.
• W2099187360 cites W1469337973 @default.
• W2099187360 cites W1964268352 @default.
• W2099187360 cites W1964464904 @default.
• W2099187360 cites W1966406375 @default.
• W2099187360 cites W1972982304 @default.
• W2099187360 cites W1976887241 @default.
• W2099187360 cites W1978560369 @default.
• W2099187360 cites W1979770573 @default.
• W2099187360 cites W1980185235 @default.
• W2099187360 cites W1982813521 @default.
• W2099187360 cites W1984737558 @default.
• W2099187360 cites W1985927968 @default.
• W2099187360 cites W1987847812 @default.
• W2099187360 cites W1989588381 @default.
• W2099187360 cites W1991702662 @default.
• W2099187360 cites W1993893889 @default.
• W2099187360 cites W1994285647 @default.
• W2099187360 cites W1994317909 @default.
• W2099187360 cites W1994805877 @default.
• W2099187360 cites W1998970893 @default.
• W2099187360 cites W2001432662 @default.
• W2099187360 cites W2005091374 @default.
• W2099187360 cites W2006204029 @default.
• W2099187360 cites W2006497939 @default.
• W2099187360 cites W2008634893 @default.
• W2099187360 cites W2010373677 @default.
• W2099187360 cites W2013669235 @default.
• W2099187360 cites W2013713870 @default.
• W2099187360 cites W2015559766 @default.
• W2099187360 cites W2017016814 @default.
• W2099187360 cites W2017079501 @default.
• W2099187360 cites W2019461671 @default.
• W2099187360 cites W2023858483 @default.
• W2099187360 cites W2024287605 @default.
• W2099187360 cites W2027417424 @default.
• W2099187360 cites W2042201192 @default.
• W2099187360 cites W2045534827 @default.
• W2099187360 cites W2047532239 @default.
• W2099187360 cites W2048388977 @default.
• W2099187360 cites W2054716445 @default.
• W2099187360 cites W2055456084 @default.
• W2099187360 cites W2058111723 @default.
• W2099187360 cites W2059093778 @default.
• W2099187360 cites W2063702351 @default.
• W2099187360 cites W2064579827 @default.
• W2099187360 cites W2066352871 @default.
• W2099187360 cites W2067108324 @default.
• W2099187360 cites W2067439408 @default.
• W2099187360 cites W2068416476 @default.
• W2099187360 cites W2071677204 @default.
• W2099187360 cites W2077220866 @default.
• W2099187360 cites W2079244891 @default.
• W2099187360 cites W2081980340 @default.
• W2099187360 cites W2082240438 @default.
• W2099187360 cites W2082868060 @default.
• W2099187360 cites W2083110718 @default.
• W2099187360 cites W2086372410 @default.
• W2099187360 cites W2089379231 @default.
• W2099187360 cites W2093444575 @default.
• W2099187360 cites W2093551683 @default.
• W2099187360 cites W2095519862 @default.
• W2099187360 cites W2097577051 @default.
• W2099187360 cites W2102320098 @default.
• W2099187360 cites W2108467445 @default.
• W2099187360 cites W2109040303 @default.
• W2099187360 cites W2110054485 @default.
• W2099187360 cites W2110374568 @default.
• W2099187360 cites W2112765817 @default.
• W2099187360 cites W2113539936 @default.
• W2099187360 cites W2115450084 @default.
• W2099187360 cites W2117910432 @default.
• W2099187360 cites W2119794733 @default.
• W2099187360 cites W2120841701 @default.
• W2099187360 cites W2121642311 @default.
• W2099187360 cites W2121732554 @default.
• W2099187360 cites W2122561085 @default.
• W2099187360 cites W2123408312 @default.
• W2099187360 cites W2126579393 @default.
• W2099187360 cites W2127237723 @default.
• W2099187360 cites W2131328232 @default.
• W2099187360 cites W2134448489 @default.
• W2099187360 cites W2134881136 @default.
• W2099187360 cites W2135795051 @default.
• W2099187360 cites W2137849205 @default.
• W2099187360 cites W2138207816 @default.
• W2099187360 cites W2140595389 @default.
• W2099187360 cites W2144037754 @default.
• W2099187360 cites W2150523249 @default.
• W2099187360 cites W2151385583 @default.
• W2099187360 cites W2152119060 @default.

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