Matches in SemOpenAlex for { <https://semopenalex.org/work/W2099200086> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2099200086 endingPage "e34" @default.
- W2099200086 startingPage "e34" @default.
- W2099200086 abstract "<h3>Objectives:</h3> To describe the clinical course and neuropathology at autopsy of a patient with neuromyelitis optica (NMO) treated with alemtuzumab. <h3>Methods:</h3> Case report. <h3>Results:</h3> A 61-year-old woman with aquaporin-4 immunoglobulin G antibody seropositive NMO had 10 clinical relapses in 4 years despite treatment with multiple immunosuppressive therapies. Alemtuzumab was administered and was redosed 15 months later. For the first 19 months after the initial alemtuzumab infusion, the patient did not experience discrete clinical relapses or have evidence of abnormally enhancing lesions on brain or spinal cord MRI. However, she experienced insidiously progressive nausea, vomiting, and vision loss, and her brain MRI revealed marked extension of cortical, subcortical, and brainstem T2/fluid-attenuated inversion recovery (FLAIR) hyperintensities. She died 20 months after the initial alemtuzumab infusion. Acute, subacute, and chronic demyelinating lesions were found at autopsy. Many of the lesions showed marked macrophage infiltration with a paucity of lymphocytes. <h3>Conclusions:</h3> Following alemtuzumab treatment, there appeared to be ongoing innate immune activation associated with tissue destruction that correlated with nonenhancing T2/FLAIR hyperintensities on MRI. We interpret the cessation of clinical relapses, absence of contrast-enhancing lesions, and scarcity of lymphocytes at autopsy to be indicative of suppression of adaptive immunity by alemtuzumab. This case illustrates that progressive worsening in NMO can occur as a consequence of tissue injury associated with monocytic infiltration. This observation may be relevant to multiple sclerosis (MS) as well as NMO and might explain why in previous studies of secondary progressive MS alemtuzumab did not seem to inhibit disability progression despite a dramatic decline in contrast-enhancing lesions." @default.
- W2099200086 created "2016-06-24" @default.
- W2099200086 creator A5015347954 @default.
- W2099200086 creator A5020903163 @default.
- W2099200086 creator A5040103144 @default.
- W2099200086 creator A5040364341 @default.
- W2099200086 creator A5045008751 @default.
- W2099200086 date "2014-10-01" @default.
- W2099200086 modified "2023-09-29" @default.
- W2099200086 title "Massive CNS monocytic infiltration at autopsy in an alemtuzumab-treated patient with NMO" @default.
- W2099200086 cites W1973218385 @default.
- W2099200086 cites W1975254445 @default.
- W2099200086 cites W1995004187 @default.
- W2099200086 cites W2002083743 @default.
- W2099200086 cites W2047062145 @default.
- W2099200086 cites W2059218087 @default.
- W2099200086 cites W2082646193 @default.
- W2099200086 cites W2087764276 @default.
- W2099200086 cites W2123746447 @default.
- W2099200086 cites W2148766438 @default.
- W2099200086 cites W2158202057 @default.
- W2099200086 doi "https://doi.org/10.1212/nxi.0000000000000034" @default.
- W2099200086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4204228" @default.
- W2099200086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25340086" @default.
- W2099200086 hasPublicationYear "2014" @default.
- W2099200086 type Work @default.
- W2099200086 sameAs 2099200086 @default.
- W2099200086 citedByCount "50" @default.
- W2099200086 countsByYear W20992000862014 @default.
- W2099200086 countsByYear W20992000862015 @default.
- W2099200086 countsByYear W20992000862016 @default.
- W2099200086 countsByYear W20992000862017 @default.
- W2099200086 countsByYear W20992000862018 @default.
- W2099200086 countsByYear W20992000862019 @default.
- W2099200086 countsByYear W20992000862020 @default.
- W2099200086 countsByYear W20992000862021 @default.
- W2099200086 countsByYear W20992000862022 @default.
- W2099200086 countsByYear W20992000862023 @default.
- W2099200086 crossrefType "journal-article" @default.
- W2099200086 hasAuthorship W2099200086A5015347954 @default.
- W2099200086 hasAuthorship W2099200086A5020903163 @default.
- W2099200086 hasAuthorship W2099200086A5040103144 @default.
- W2099200086 hasAuthorship W2099200086A5040364341 @default.
- W2099200086 hasAuthorship W2099200086A5045008751 @default.
- W2099200086 hasBestOaLocation W20992000861 @default.
- W2099200086 hasConcept C101070640 @default.
- W2099200086 hasConcept C126838900 @default.
- W2099200086 hasConcept C142724271 @default.
- W2099200086 hasConcept C143409427 @default.
- W2099200086 hasConcept C146638467 @default.
- W2099200086 hasConcept C159654299 @default.
- W2099200086 hasConcept C203014093 @default.
- W2099200086 hasConcept C2779015954 @default.
- W2099200086 hasConcept C2779504383 @default.
- W2099200086 hasConcept C2780640218 @default.
- W2099200086 hasConcept C2781137167 @default.
- W2099200086 hasConcept C71924100 @default.
- W2099200086 hasConceptScore W2099200086C101070640 @default.
- W2099200086 hasConceptScore W2099200086C126838900 @default.
- W2099200086 hasConceptScore W2099200086C142724271 @default.
- W2099200086 hasConceptScore W2099200086C143409427 @default.
- W2099200086 hasConceptScore W2099200086C146638467 @default.
- W2099200086 hasConceptScore W2099200086C159654299 @default.
- W2099200086 hasConceptScore W2099200086C203014093 @default.
- W2099200086 hasConceptScore W2099200086C2779015954 @default.
- W2099200086 hasConceptScore W2099200086C2779504383 @default.
- W2099200086 hasConceptScore W2099200086C2780640218 @default.
- W2099200086 hasConceptScore W2099200086C2781137167 @default.
- W2099200086 hasConceptScore W2099200086C71924100 @default.
- W2099200086 hasIssue "3" @default.
- W2099200086 hasLocation W20992000861 @default.
- W2099200086 hasLocation W20992000862 @default.
- W2099200086 hasLocation W20992000863 @default.
- W2099200086 hasLocation W20992000864 @default.
- W2099200086 hasLocation W20992000865 @default.
- W2099200086 hasOpenAccess W2099200086 @default.
- W2099200086 hasPrimaryLocation W20992000861 @default.
- W2099200086 hasRelatedWork W2048761373 @default.
- W2099200086 hasRelatedWork W2099200086 @default.
- W2099200086 hasRelatedWork W2138683696 @default.
- W2099200086 hasRelatedWork W2166774287 @default.
- W2099200086 hasRelatedWork W2180241394 @default.
- W2099200086 hasRelatedWork W3031286282 @default.
- W2099200086 hasRelatedWork W3033367471 @default.
- W2099200086 hasRelatedWork W3137519083 @default.
- W2099200086 hasRelatedWork W4384818991 @default.
- W2099200086 hasRelatedWork W66911304 @default.
- W2099200086 hasVolume "1" @default.
- W2099200086 isParatext "false" @default.
- W2099200086 isRetracted "false" @default.
- W2099200086 magId "2099200086" @default.
- W2099200086 workType "article" @default.