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- W2099207814 abstract "SummaryWhen ampicillin is given by intramuscular injections at six-hourly intervals to pregnant women, it reaches levels in the fetus which are almost one-third of the maternal levels. The delay in reaching the liquor amnii is less than after oral administration of antibiotic and after four to six hours reaches 4 μg. per ml. There is no evidence of accumulation with repeated dosage. Cephaloridine behaves in a similar manner to ampicillin and there is no evidence of accumulation in the fetus. Cephalothin produced short-lived high levels in the maternal serum but in the liquor amnii levels of 4 μg. per ml. were reached very rapidly and sustained. Only small quantities of cephalothin were found in the fetus and it is considered that this was related to the route of administration. The findings suggest that when ampicillin, cephaloridine or cephalothin are used to treat severe intrauterine infections during labour, both the intravenous and intramuscular routes of administration should be used as the former quickly give high levels of antibiotic in liquor amnii, while the latter give sustained levels in the fetus." @default.
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- W2099207814 date "1973-10-01" @default.
- W2099207814 modified "2023-09-26" @default.
- W2099207814 title "DISTRIBUTION OF PARENTERAL AMPICILLIN AND CEPHALOSPORINS IN LATE PREGNANCY" @default.
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- W2099207814 doi "https://doi.org/10.1111/j.1471-0528.1973.tb02149.x" @default.
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