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• W2099208314 startingPage "R77" @default.
• W2099208314 abstract "Excessive dopamine (DA) is known to cause hypoxic/ischemic damage to mammalian brain. The freshwater turtle Trachemys scripta, however, maintains basal striatal DA levels in anoxia. We investigated DA balance during early anoxia when energy status in the turtle brain is compromised. The roles of ATP-sensitive potassium (K ATP ) channels and adenosine (AD) receptors were investigated as these factors affect DA balance in mammalian neurons. Striatal extracellular DA was determined by microdialysis with HPLC in the presence or absence of the specific DA transport blocker GBR-12909, the K ATP blocker 2,3-butanedione monoxime, or the nonspecific AD receptor blocker theophylline. We found that in contrast to long-term anoxia, blocking DA reuptake did not significantly increase extracellular levels in 1-h anoxic turtles. Low DA levels in early anoxia were maintained instead by activation of K ATP channels and AD receptors. Blocking K ATP resulted in a 227% increase in extracellular DA in 1-h anoxic turtles but had no effect after 4 h of anoxia. Similarly, blocking AD receptors increased DA during the first hour of anoxia but did not change DA levels at 4-h anoxia. Support for the role of K ATP channels in DA balance comes from normoxic animals treated with K ATP opener; infusing diazoxide but not adenosine into the normoxic turtle striatum resulted in an immediate DA decrease to 14% of basal values within 1.5 h. Alternative strategies to maintain low extracellular levels may prevent catastrophic DA increases when intracellular energy is compromised while permitting the turtle to maintain a functional neuronal network during long-term anoxia." @default.
• W2099208314 created "2016-06-24" @default.
• W2099208314 creator A5021991308 @default.
• W2099208314 creator A5068836528 @default.
• W2099208314 date "2005-07-01" @default.
• W2099208314 modified "2023-09-23" @default.
• W2099208314 title "Adenosine and ATP-sensitive potassium channels modulate dopamine release in the anoxic turtle (<i>Trachemys scripta</i>) striatum" @default.
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• W2099208314 doi "https://doi.org/10.1152/ajpregu.00647.2004" @default.
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• W2099208314 hasPublicationYear "2005" @default.
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