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• W2099209468 abstract "The purpose of this investigation was to monitor the localization and migration of I-125 seeds after permanent brachytherapy for prostate cancer using a new scintigraphic technique that may overcome the drawbacks of conventional X-ray methods. The I-125 seeds emit gamma rays with an average energy peak of 28 keV. We used a gamma camera equipped with low-energy high-resolution collimators that were tuned to an energy level of 35 keV with a 70% window width. Sixteen patients with prostate cancer were examined after I-125 seed insertion. The number of seeds remaining in the prostate was confirmed using pelvic computed tomography (CT) for postoperative dose planning; however, seeds that had migrated outside the prostate could not be fully detected. Furthermore, the migrated seeds were not completely traceable using chest or abdominal radiographies. Thus, we adopted a scintigraphic technique to perform this task. The radiographies and scintigraphies were evaluated blindly, and the rates of migrated seed detection were statistically examined using the McNamen test. To localize the migrated seeds, we composed fusion images of scintigraphies of the migrated seeds and the patients' contours. Scintigraphy was successfully used to detect 20 migrated seeds out of a total of 1182 implanted seeds, while radiography was successfully used to detect seven. The sensitivity of the scintigraphy results was 20/20 (100%), while that of the radiography results was 7/20 (35%). Seed migration was detected in 11 out of 16 patients (69%) using scintigraphy, whereas seed migration was only detected in 4 patients (25%) using radiography; this difference was statistically significant (p = 0.016). Scintillation cameras are more effective for detecting seed migration and monitoring the localization of I-125 seeds than radiography. The precise anatomical location of migrated seeds can be pinpointed using fusion images. If the detection rate of migration is dramatically improved, we can search possible factors associated with seed migration. That may improve the seed implantation technique and may help the quality control of brachytherapy. Scintigraphy may become a standard procedure for monitoring seed migration during I-125 brachytherapy in patients with prostate cancer." @default.
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• W2099209468 date "2008-09-01" @default.
• W2099209468 modified "2023-09-24" @default.
• W2099209468 title "Scintigraphic Detection of Iodide-125 Seeds after Permanent Brachytherapy for Prostate Cancer" @default.
• W2099209468 doi "https://doi.org/10.1016/j.ijrobp.2008.06.1107" @default.
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