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- W2099221370 abstract "Mass spectrometry-based analyses of the low-molecular-weight fraction of serum proteome allow identifying proteome profiles (signatures) that are potentially useful in detection and classification of cancer. Several published studies have shown that multipeptide signatures selected in numerical tests have potential values for diagnostics of different types of cancer. However due to apparent problems with standardization of methodological details, both experimental and computational, none of the proposed peptide signatures analyzed directly by MALDI/SELDI-ToF spectrometry has been approved for routine diagnostics. Noteworthy, several components of proposed cancer signatures, especially those characteristic for advanced cancer, were identified as fragments of blood proteins involved in the acute phase and inflammatory response. This indicated that among cancer biomarker candidates to be possibly identified by serum proteome profiling were rather those reflecting overall influence of a disease (and the therapy) upon the human organism, than products of cancer-specific genes. Current paper focuses on changes in serum proteome that are related to response of patient's organism to progressing malignancy and toxicity of anticancer treatment. In addition, several methodological issues that affect robustness and interlaboratory reproducibility of MS-based serum proteome profiling are discussed." @default.
- W2099221370 created "2016-06-24" @default.
- W2099221370 creator A5037979882 @default.
- W2099221370 creator A5050285030 @default.
- W2099221370 date "2012-07-30" @default.
- W2099221370 modified "2023-10-18" @default.
- W2099221370 title "MALDI-MS-Based Profiling of Serum Proteome: Detection of Changes Related to Progression of Cancer and Response to Anticancer Treatment" @default.
- W2099221370 cites W131174036 @default.
- W2099221370 cites W1536912963 @default.
- W2099221370 cites W1964638171 @default.
- W2099221370 cites W1970191747 @default.
- W2099221370 cites W1973389945 @default.
- W2099221370 cites W1973986822 @default.
- W2099221370 cites W1977729648 @default.
- W2099221370 cites W1981524290 @default.
- W2099221370 cites W1987266144 @default.
- W2099221370 cites W1987851205 @default.
- W2099221370 cites W1992730111 @default.
- W2099221370 cites W1998097661 @default.
- W2099221370 cites W2000024255 @default.
- W2099221370 cites W2004099167 @default.
- W2099221370 cites W2008090557 @default.
- W2099221370 cites W2009368567 @default.
- W2099221370 cites W2011896331 @default.
- W2099221370 cites W2014843640 @default.
- W2099221370 cites W2018337229 @default.
- W2099221370 cites W2023096047 @default.
- W2099221370 cites W2024633121 @default.
- W2099221370 cites W2024720397 @default.
- W2099221370 cites W2031174828 @default.
- W2099221370 cites W2042708504 @default.
- W2099221370 cites W2043256631 @default.
- W2099221370 cites W2044803236 @default.
- W2099221370 cites W2045634898 @default.
- W2099221370 cites W2046056818 @default.
- W2099221370 cites W2046597088 @default.
- W2099221370 cites W2046853584 @default.
- W2099221370 cites W2048040326 @default.
- W2099221370 cites W2052266313 @default.
- W2099221370 cites W2053217908 @default.
- W2099221370 cites W2061883165 @default.
- W2099221370 cites W2063862404 @default.
- W2099221370 cites W2067839399 @default.
- W2099221370 cites W2073963914 @default.
- W2099221370 cites W2076799660 @default.
- W2099221370 cites W2077523260 @default.
- W2099221370 cites W2078859186 @default.
- W2099221370 cites W2083512912 @default.
- W2099221370 cites W2086207150 @default.
- W2099221370 cites W2088062696 @default.
- W2099221370 cites W2091571600 @default.
- W2099221370 cites W2095673758 @default.
- W2099221370 cites W2096243555 @default.
- W2099221370 cites W2099061159 @default.
- W2099221370 cites W2099224936 @default.
- W2099221370 cites W2101147096 @default.
- W2099221370 cites W2101560421 @default.
- W2099221370 cites W2109951346 @default.
- W2099221370 cites W2112248044 @default.
- W2099221370 cites W2112899213 @default.
- W2099221370 cites W2112909603 @default.
- W2099221370 cites W2113818244 @default.
- W2099221370 cites W2114125856 @default.
- W2099221370 cites W2119908867 @default.
- W2099221370 cites W2120501961 @default.
- W2099221370 cites W2121002866 @default.
- W2099221370 cites W2121165523 @default.
- W2099221370 cites W2121916988 @default.
- W2099221370 cites W2126134338 @default.
- W2099221370 cites W2126432898 @default.
- W2099221370 cites W2126897927 @default.
- W2099221370 cites W2132268174 @default.
- W2099221370 cites W2133886319 @default.
- W2099221370 cites W2134213739 @default.
- W2099221370 cites W2134389439 @default.
- W2099221370 cites W2138482047 @default.
- W2099221370 cites W2139660350 @default.
- W2099221370 cites W2142096976 @default.
- W2099221370 cites W2143233121 @default.
- W2099221370 cites W2146146709 @default.
- W2099221370 cites W2146470803 @default.
- W2099221370 cites W2150160398 @default.
- W2099221370 cites W2154621549 @default.
- W2099221370 cites W2157492758 @default.
- W2099221370 cites W2157995152 @default.
- W2099221370 cites W2158826156 @default.
- W2099221370 cites W2161463151 @default.
- W2099221370 cites W2162355650 @default.
- W2099221370 cites W2165487340 @default.
- W2099221370 cites W2167244585 @default.
- W2099221370 cites W2167328524 @default.
- W2099221370 cites W2167409896 @default.
- W2099221370 cites W2171764600 @default.
- W2099221370 cites W2172007544 @default.
- W2099221370 cites W2172116519 @default.
- W2099221370 cites W2172300860 @default.
- W2099221370 cites W2325048732 @default.
- W2099221370 cites W4237585456 @default.