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- W2099224719 endingPage "1166" @default.
- W2099224719 startingPage "1164" @default.
- W2099224719 abstract "Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six PTPs ( PTPRF, PTPRG, PTPRT, PTPN3, PTPN13, PTPN14 ), affecting 26% of colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. Fifteen mutations were nonsense, frameshift, or splice-site alterations predicted to result in truncated proteins lacking phosphatase activity. Five missense mutations in the most commonly altered PTP ( PTPRT ) were biochemically examined and found to reduce phosphatase activity. Expression of wild-type but not a mutant PTPRT in human cancer cells inhibited cell growth. These observations suggest that the mutated tyrosine phosphatases are tumor suppressor genes, regulating cellular pathways that may be amenable to therapeutic intervention." @default.
- W2099224719 created "2016-06-24" @default.
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- W2099224719 date "2004-05-21" @default.
- W2099224719 modified "2023-10-01" @default.
- W2099224719 title "Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers" @default.
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- W2099224719 doi "https://doi.org/10.1126/science.1096096" @default.
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