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• W2099225274 abstract "We analyzed the sera of patients with melanoma to define the human humoral autoantibody profile towards HMW-MAA. Computational proteome scanning using the non-self-discrimination principle as a guide led to the individuation of the low-similarity HMW-MAA781-789RATVWMLRL peptide fragment as an immunodominant B-cell epitope. Linear B-cell determinant individuation was experimentally validated by dot blot immunoassay and NMR spectroscopy analysis. Regulation of physiologic self-reactivity by the non-self-discrimination principle is discussed." @default.
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• W2099225274 date "2004-01-01" @default.
• W2099225274 modified "2023-10-07" @default.
• W2099225274 title "Non-self-discrimination as a driving concept in the identification of an immunodominant HMW-MAA epitopic peptide sequence by autoantibodies from melanoma cancer patients" @default.
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• W2099225274 doi "https://doi.org/10.1002/ijc.20310" @default.
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